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A Study Investigating a Possible Link Between Lens Protein in the Vitreous Fluid of Eyes After Uncomplicated Cataract Surgery and Chronic Cystoid Macular Edema

Thompson, Andrew M. FRANZCO; Chee, Kaa-Sandra N. PhD; Loh, I-Ping MSc; Sherwin, Trevor PhD; Green, Colin R. PhD; Polkinghorne, Philip J. MD

The Asia-Pacific Journal of Ophthalmology: May/June 2014 - Volume 3 - Issue 3 - p 194–197
doi: 10.1097/APO.0000000000000011
Laboratory Science

Purpose This study aimed to determine if the lens protein aquaporin 0 (AQP0) is present in the vitreous of pseudophakic eyes of patients presenting with chronic cystoid macular edema (CME).

Design A case-control study was conducted.

Methods Ten patients undergoing therapeutic vitrectomy for chronic CME after uncomplicated cataract surgery were enrolled in this study. Fourteen patients with pseudophakia undergoing vitrectomy surgery for indications other than CME acted as the comparison group.

The vitreous fluid from the 2 groups was analyzed for the presence of the lens protein AQP0 and type II collagen (used as a positive control).

Results Type II collagen was detected in all the vitreous samples, whereas AQP0 was documented in 50% of eyes with chronic CME but was not found in the vitreous of any eyes without a documented history of CME.

Conclusions Aquaporin 0 is found in some eyes with chronic CME after uncomplicated cataract surgery, suggesting contamination of the vitreous by lens protein may have a role in the pathogenesis of this disorder.

From the Department of Ophthalmology, Faculty of Medicine, University of Auckland, Auckland, New Zealand.

Received for publication May 17, 2013; accepted August 30, 2013.

The authors have no funding or conflicts of interest to declare.

Reprints: Philip J. Polkinghorne, MD, Department of Ophthalmology, 37 Park Street, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand. E-mail:

© 2014 by Asia Pacific Academy of Ophthalmology
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