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Propranolol suppresses infantile hemangioma cell proliferation and promotes apoptosis by upregulating miR-125b expression

Huang, Jiajiaa; Jiang, Dongdongb; Zhao, Shashab; Wang, Aifenga

doi: 10.1097/CAD.0000000000000762
PRECLINICAL REPORTS
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Propranolol could repress infantile hemangioma cell growth and induce apoptosis. miR-125b could inhibit cell proliferation in some tumors. However, whether propranolol exerts its proliferation inhibition and apoptosis-promoting effect by regulating the expression of miR-125b needs to be further investigated. In tumor tissue and endothelial cells isolated from infantile hemangioma patients, we found that the expression levels of miR-125b were significantly decreased. In-vitro analysis revealed that propranolol increased the expression of miR-125b in hemangioma cells in a dose-dependent and time-dependent manner. Interestingly, it was observed that regression of miR-125b expression by its inhibitor could abrogate the effect of propranolol on hemangioma cell growth and apoptosis. In addition, our data further identified TFAP4 as a direct target of miR-125b. Collectively, our data provided evidence that propranolol may repress infantile hemangioma cell growth and promote apoptosis through upregulating the miR-125b expression, which exerted its suppression of tumor development by targeting TFAP4.

aDepartment of Pharmacy, Fuwai Central China Cardiovascular Hospital

bCollege of Pharmacy, Zhengzhou University, Zhengzhou, People’s Republic of China

Correspondence to Jiajia Huang, MSc, Fuwai Central China Cardiovascular Hospital, Department of Pharmacy, Henan, Zhengzhou 450000, People’s Republic of China Tel/fax: +86 037 158 680 510; e-mail: huijia1028@163.com

Received October 17, 2018

Accepted January 21, 2019

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