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Oxazaphosphorine cytostatics

from serendipity to rational drug design

Voelcker, Georg

doi: 10.1097/CAD.0000000000000782
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On the basis of the discovery that the proapoptotic aldehyde 3-hydroxypropanal is a cyclophosphamide metabolite, a novel mechanism of action of oxazaphosphorine cytostatics is presented and confirmed by animal experiments. Furthermore, it is shown that new oxazaphosphorine cytostatics, which are on orders of magnitude more effective than already existing, can be developed on the basis of the new model for the mechanism of action.

Institute of Biochemistry II, Goethe University Frankfurt Medical School, Frankfurt, Germany

Correspondence to Georg Voelcker, PhD, Institute of Biochemistry II, Goethe University Frankfurt Medical School, 60590 Frankfurt, Germany Tel: +49 696 301 5652; fax: +49 696 301 5577; e-mails: voelcker@biochem2.uni-frankfurt.de, voelckerdr@aol.com

Received January 4, 2019

Accepted February 25, 2019

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