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Immunogenicity moderation effect of interleukin-24 on myelogenous leukemia cells

Yu, Xina,b; Miao, Jingchengb; Xia, Weia; Gu, Zong-Jiangb

doi: 10.1097/CAD.0000000000000606
PRECLINICAL REPORTS
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Previous studies have shown that interleukin-24 (IL-24) has tumor-suppressing activity by multiple pathways. However, the immunogenicity moderation effect of IL-24 on malignant cells has not been explored extensively. In this study, we investigated the role of IL-24 in immunogenicity modulation of the myelogenous leukemia cells. Data show that myelogenous leukemia cells express low levels of immunogenicity molecules. Treatment with IL-24 could enhance leukemia cell immunogenicity, predominantly regulate leukemia cells to produce immune-associated cytokines, and improve the cytotoxic sensitivity of these cells to immune effector cells. IL-24 expression could retard transplanted leukemia cell tumor growth in vivo in athymic nude mice. Moreover, IL-24 had marked effects on downregulating the expression of angiogenesis-related proteins vascular endothelial growth factor, cluster of differentiation (CD) 31, CD34, collagen IV and metastasis-related factors CD147, membrane type-1 matrix metalloproteinase (MMP), and MMP-2 and MMP-9 in transplanted tumors. These findings indicated novel functions of this antitumor gene and characterized IL-24 as a promising agent for further clinical trial for hematologic malignancy immunotherapy.

aBlood Transfusion Research Institute, Wuxi Red Cross Blood Center, Wuxi

bMedical Biotechnology Institute, Soochow University, Suzhou, People’s Republic of China

Correspondence to Zong-Jiang Gu, PhD, Medical Biotechnology Institute, Soochow University, Suzhou, Jiangsu 215007, People’s Republic of China Tel: +86 512 6512 5011; e-mail: szguzj@163.com

Received September 25, 2017

Accepted January 19, 2018

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