Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Penicillium spp.: prolific producer for harnessing cytotoxic secondary metabolites

Koul, Mytre; Singh, Shashank

doi: 10.1097/CAD.0000000000000423

Secondary metabolites from fungal endophytes have become an interesting, attractive, and alternative source for novel pharmaceuticals. Several novel compounds with diversified chemical structures have been isolated from endophytic fungi. The genus Penicillium has been exploited worldwide for its biosynthetic potential for producing highly versatile cytotoxic secondary metabolites. Many of the compounds isolated from various species of the genus Penicillium have shown promising in-vitro as well as in-vivo growth-inhibitory properties against different human cancers. Thus, in relation to this genus, Penicillium represents the most dependable source of cytotoxic compounds with potential applications as leads for anticancer drugs. This review outlines endophytic secondary metabolites from the genus Penicillium with a relevant role as cytotoxic agents.

aCancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir

bAcademy of Scientific & Innovative Research (AcSIR), CSIR, New Delhi, India

Correspondence to Shashank Singh, MPharm, PhD, Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, Jammu and Kashmir, India Tel: +91 191 2585006 13 x352; fax: +91 191 2569019; e-mails:;

Received May 8, 2016

Accepted July 24, 2016

Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.