Complete remissions in afatinib-treated non-small-cell lung cancer patients with symptomatic brain metastasesHochmair, Maximilian; Holzer, Sophia; Burghuber, Otto C.Anti-Cancer Drugs: October 2016 - Volume 27 - Issue 9 - p 914–915 doi: 10.1097/CAD.0000000000000410 CASE REPORTS Buy Abstract Author InformationAuthors Article MetricsMetrics In patients with non-small-cell lung cancer, the presence of brain metastases requires specific treatment due to the unfavourable overall impact of these lesions. Treatment with the tyrosine kinase inhibitor afatinib was shown to induce complete and long-lasting remissions in the five patients described here. All of them had multiple brain lesions and presented with symptoms. Study evidence suggests beneficial effects of afatinib in this respect, underlining these clinical observations. Afatinib might be incorporated into current treatment algorithms, allowing for the omission of radiotherapy, provided that larger phase III trials confirm the potential of epidermal growth factor receptor tyrosine kinase inhibitors in this respect. Respiratory Oncology Unit, Department of Respiratory and Critical Care Medicine, Otto-Wagner-Spital, Vienna, Austria Correspondence to Maximilian Hochmair, MD, Respiratory Oncology Unit, Department of Respiratory and Critical Care Medicine, Otto-Wagner-Spital, Sanatoriumstrasse 2, Vienna 1140, Austria Tel: +43 1 910 6041240; fax: +43 1 910 6041823;e-mail: email@example.com Received May 15, 2016 Accepted June 25, 2016 Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.