Long-term survival in small-cell carcinoma of the endometrium with liver and brain metastasesSawada, Masaakia,b; Matsuzaki, Shinyaa; Yoshino, Kiyoshia; Ueda, Yutakaa; Yoshida, Susumub; Kimura, Tadashia; Ogita, KazuhidebAnti-Cancer Drugs: February 2016 - Volume 27 - Issue 2 - p 138–143 doi: 10.1097/CAD.0000000000000289 CASE REPORTS Buy Abstract Author InformationAuthors Article MetricsMetrics Small-cell carcinoma (SmCC) of the endometrium is an extremely rare cancer and has a poor prognosis. Because long-term survival is rare, there is a paucity of data on the advanced disease stages. Thus, a standard treatment has not been established. We describe an extremely rare case of long-term survival in SmCC of the endometrium with liver and brain metastases. We provided multidisciplinary treatment, including brain surgery, subsequent whole-brain radiotherapy, gynecologic surgery, and adjuvant chemotherapy (irinotecan hydrochloride+cisplatin). The patient was treated successfully and has survived for more than 12 years with no evidence of the disease. Irinotecan hydrochloride+cisplatin chemotherapy was effective for controlling the liver metastases, and the resection of brain metastases and radiotherapy were effective for the treatment of brain metastases in our case. We reviewed the pertinent literature of advanced SmCC of the endometrium. aDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka bDepartment of Obstetrics and Gynecology, Rinku General Medical Center, Osaka, Japan Correspondence to Shinya Matsuzaki, MD, PhD, Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan Tel: +81 6 6879 3355; fax: +81 6 6879 3359; e-mail: firstname.lastname@example.org Received May 19, 2015 Accepted August 10, 2015 Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.