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Long-term survival in small-cell carcinoma of the endometrium with liver and brain metastases

Sawada, Masaakia,b; Matsuzaki, Shinyaa; Yoshino, Kiyoshia; Ueda, Yutakaa; Yoshida, Susumub; Kimura, Tadashia; Ogita, Kazuhideb

doi: 10.1097/CAD.0000000000000289

Small-cell carcinoma (SmCC) of the endometrium is an extremely rare cancer and has a poor prognosis. Because long-term survival is rare, there is a paucity of data on the advanced disease stages. Thus, a standard treatment has not been established. We describe an extremely rare case of long-term survival in SmCC of the endometrium with liver and brain metastases. We provided multidisciplinary treatment, including brain surgery, subsequent whole-brain radiotherapy, gynecologic surgery, and adjuvant chemotherapy (irinotecan hydrochloride+cisplatin). The patient was treated successfully and has survived for more than 12 years with no evidence of the disease. Irinotecan hydrochloride+cisplatin chemotherapy was effective for controlling the liver metastases, and the resection of brain metastases and radiotherapy were effective for the treatment of brain metastases in our case. We reviewed the pertinent literature of advanced SmCC of the endometrium.

aDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka

bDepartment of Obstetrics and Gynecology, Rinku General Medical Center, Osaka, Japan

Correspondence to Shinya Matsuzaki, MD, PhD, Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan Tel: +81 6 6879 3355; fax: +81 6 6879 3359; e-mail:

Received May 19, 2015

Accepted August 10, 2015

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