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Renal cell cancer metastases to esophagus and stomach successfully treated with radiotherapy and pazopanib

Cabezas-Camarero, Santiagoa; Puente, Javiera; Manzano, Aránzazua; Corona, Juan Antoniob; González-Larriba, José Luisa; Bernal-Becerra, Israelc; Sotelo, Miguela; Díaz-Rubio, Eduardoa

doi: 10.1097/CAD.0000000000000150

Renal cell cancer has been rarely reported as a cause of gastric or esophageal metastases. They usually present with gastrointestinal bleeding and most cases have been managed surgically or endoscopically. We report the case of a 38-year-old man with a 4-year history of metastatic renal cell carcinoma admitted to the emergency room with melena and anemia. At endoscopy, three esophageal polypoid lesions (middle and distal thirds) and a 7 cm mass in the gastric fundus were identified. Biopsy revealed esophageal mucosa infiltrated by renal cell carcinoma. Radiotherapy was administered (30 Gy in 10 fractions), followed by pazopanib, with excellent tolerance and without new bleeding episodes. Computed tomography scan showed complete disappearance of the esophageal and fundic lesions at 3 months follow-up. Twenty-four months after being initiated on pazopanib, there is no radiological evidence of disease. This is the first reported case showing complete remission of gastric and esophageal metastases after treatment with radiotherapy and pazopanib.

Departments of aMedical Oncology

bRadiation Oncology

cPathology Center affiliated to the “Red Temática de Investigación Cooperativa (RD12/0036/006)”, Instituto Carlos III, Spanish Ministry of Economy and Competitivity, Hospital Clínico San Carlos, 28040 Madrid, Spain

Correspondence to Santiago Cabezas-Camarero, MD, Department of Medical Oncology, Hospital Clínico Universitario San Carlos, Profesor Martín Lagos S/N, 28040 Madrid, Spain Tel: +34 91 330 3649/3546; fax: +34 91 330 3546; e-mails:,

Received March 29, 2014

Accepted June 18, 2014

© 2015 Wolters Kluwer Health | Lippincott Williams & Wilkins