Clinical report: PDF OnlyA prospective cohort study of the effect of vincristine on auditionLugassy, Gilles1; Shapira, Amnon2Author Information 1Institute of Hematology, Head and Neck Surgery, Barzilai Medical Center, Ashkelon, Israel. 2Department of Otolaryngology, Head and Neck Surgery, Barzilai Medical Center, Ashkelon, Israel. Tel:/Fax: (+972) 7–745490. Affiliated to the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheva, Israel. Anti-Cancer Drugs: July 1996 - Volume 7 - Issue 5 - p 525-526 Buy Abstract We conducted a prospective cohort study of the possible ototoxic effect of vincristine among patients treated for lymphoproliferative malignancies. No deleterious effect of moderate doses of vincristine on pure tone audiometry for air and bone conduction and on speech audiometry could be found. Nevertheless, the Isolated finding of sensorineural hearing loss in the only patient who received a high dose of vincristine raises the issue of ototoxicity as a possible dose-related and dose-limiting side effect of vincristine. © Lippincott-Raven Publishers.