Review paper: PDF OnlyClinical experience with intravenous granisetronSoukop, Michael Author Information Department of Medical Oncology, Royal Infirmary, Glasgow G4 0SF, UK. Fax: (+44) 41 304 4855. Anti-Cancer Drugs: June 1994 - Volume 5 - Issue 3 - p 281 Buy Abstract This review discusses the development and use of 5-hydroxytryptamine3 (5-HT3) antagonists, especially granisetron, for the treatment of chemotherapy-induced emesis. Following recent evidence suggesting that high-dose chemotherapy is more effective in increasing tumor response rate and median survival time, more effective antiemetic control is essential. Granisetron, a new 5-HT3, is approximately 400 times more potent than metoclopramide and, unlike metoclopramide, does not produce extrapyramidal side effects. Granisetron has been shown to be effective as a single prophylactic dose, over 5 days and in patients receiving repeated cycles of chemotherapy. Patients with nausea and vomiting within the first 24 h after chemotherapy are more likely to experience delayed symptoms; however, episodes of breakthrough nausea and vomiting can be controlled by intervention with one, and in some cases more, doses of granisetron. The development of granisetron represents an important advance in the control of chemotherapy induced emesis. © Lippincott-Raven Publishers.
