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Abnormal Presentation of Aggressive Fibromatosis After Radiotherapy for Keloids

Case Report and Brief Literature Review

Chen, Yuan BS*; Chen, Yue BS*; Liu, Yong PhD

doi: 10.1097/SAP.0000000000001675
Review Paper
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Rationale Keloids, dermal fibroproliferative lesions, often occur secondary to skin injury and extend beyond the margins of the original lesion. Aggressive fibromatosis (AF) is a rare condition arising from fibroblasts and is characterized clinically as a nonmetastasizing but locally invasive tumor. In this work, we present the case of a patient who developed AF in the chest 3 years after surgery and postoperative radiotherapy for keloids.

Patient Concerns A 15-year-old female patient who underwent surgery and postoperative radiotherapy for keloids presented with AF in the chest 3 years after intervention.

Diagnoses and Outcomes Physical examination revealed a fan-shaped scar on the manubrium sterni with a radius of 7 cm, as well as a 9 (L) × 2-cm (W) longitudinal reddish and irregularly surfaced scar arising from previous incisions. By comparing this case with similar cases reported previously, we infer that a history of exposure to radiation is the main factor that contributes to the development of AF in patients suffering from keloid scars. We also discussed the clinical characteristics of AF and treatment options and suggest factors that should be considered when using radiotherapy in patients with keloids.

Lessons To our knowledge, this is the first reported case of AF developing in a patient after radiotherapy for keloids. Radiotherapy may be a causal factor of AF.

From the *West China School of Stomatology and

Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Received July 2, 2018, and accepted for publication, after revision August 30, 2018.

Yuan Chen and Yue Chen contributed equally to this work.

Conflicts of interest and sources of funding: none declared.

This study was approved by the institutional review boards of Sichuan University (Chengdu, China) and West China Hospital. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional review boards of Sichuan University (Chengdu, China) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Written informed consent was obtained from all individual participants included in the study.

Reprints: Yong Liu, PhD, Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Guoxue Lane, Chengdu, Sichuan 610041, People's Republic of China. E-mail: liu.yong7088@163.com.

Online date: December 17, 2018

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