CraniofacialManaging Vascular Anomalies in the Era of Genetics and Precision Medicine An Opportunity or a Challenge?Gu, Hao MDa; Liu, Hongyuan MDa; Cai, Ren MDb; Chen, Hui MDa; Lin, Xiaoxi MD, PhDaAuthor Information From the aDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital School of Medicine bBio-X Institute, Shanghai Jiao Tong University, Shanghai, People's Republic of China. Received May 4, 2020, and accepted for publication, after revision November 27, 2020. H.G. and H.L. contributed equally to this article. Conflicts of interest and sources of funding: Clinical Research Program of Shanghai Municipal Health Commission (202040433) and the Clinical Research Plan of Shanghai Hospital Development Center (SHDC2020CR2036B). Reprints: Xiaoxi Lin, MD, PhD, Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, People's Republic of China 200011. E-mail: [email protected]; Hui Chen, MD, Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, People's Republic of China 200011. E-mail: [email protected]. Annals of Plastic Surgery: March 2021 - Volume 86 - Issue 3S - p S269-S272 doi: 10.1097/SAP.0000000000002723 Buy Metrics Abstract The era of genetics and precision medicine has been reforming this world. How will plastic surgeons in the field of vascular anomalies conform to the trend? This article systematically reviews the identification of serum biomarkers, risk factors, specific mutations in the angiogenesis-related genes such as GNAQ, RASA1, TEK, and their impact on the diagnosis and treatment of vascular anomalies with preliminary results that have been previously reported and leading the tide. Moreover, a new disease classification for complex vascular malformations based on PIK3CA genetic evidence and various treatment breakthroughs is briefly summarized. With gene sequencing, bioinformatics, and big data, we confront the challenges of research in the vascular anomalies domain and explore possibilities of precision medicine development. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.