Review PaperFibrin Glue and Its Alternatives in Peripheral Nerve RepairChow, Nathan BSa; Miears, Hunter BSa; Cox, Cameron BBAa,b; MacKay, Brendan MDa,bAuthor Information From the aDepartment of Orthopaedic Surgery, Texas Tech University Health Sciences Center bDepartment of Orthopaedic Surgery, University Medical Center, Lubbock, TX. Received September 26, 2019, and accepted for publication, after revision March 11, 2020. Conflicts of interest and sources of funding: although this case report was not directly funded by any grant, Texas Tech University Department of Orthopedics does receive funding and grant awards to participate in the nationwide RANGER nerve allograft trial as well as investigating uses of AVIVE (human umbilical membrane) sponsored by Axogen. The authors declare no conflict of interest. Reprints: Cameron Cox, BBA, Department of Orthopaedic Surgery, Texas Tech Health Sciences Center, Mail Stop 9436, 3601 4th St, Lubbock, TX 79430-9436. E-mail: [email protected]. Annals of Plastic Surgery: January 2021 - Volume 86 - Issue 1 - p 103-108 doi: 10.1097/SAP.0000000000002408 Buy Metrics Abstract Over the past century, many advancements have been made in peripheral nerve repair, yet these reconstructions still remain a challenge. Although sutures have historically been used for neurorrhaphy, they sometimes fail to provide optimal outcomes. As a result, multiple adhesive compounds are currently being investigated for their efficacy in nerve repair. Recently, fibrin glue has shown utility in peripheral nerve repair, and the body of evidence supporting its use continues to grow. Fibrin glue has been shown to reduce inflammation, improve axonal regeneration, and provide excellent functional results. This alternative to traditional suture neurorrhaphy could potentially improve outcomes of peripheral nerve reconstruction. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.