Peripheral Nerve Surgery and ResearchCadaver Nerve Grafts Past, Present and FuturePuente-Espel, Jordi MDa; Chang, Jeremy MSb; Liu, Xiangxia MDa; Riccio, Charles A. MDa; Konofaos, Petros MD, PhDaAuthor Information From the aDepartment of Plastic Surgery bCollege of Medicine, Memphis Campus, University of Tennessee Health Science Center, Memphis, TN. Received August 12, 2019, and accepted for publication, after revision December 5, 2019. Conflicts of interest and sources of funding: none declared. The senior author P.K. is a consultant with Axogen but he did not receive any payment for the current article. Reprints: Petros Konofaos, MD, PhD, 1068 Cresthaven Rd, Suite 500. Memphis, TN 38119. E-mail: firstname.lastname@example.org. Online date: February 7, 2020 Annals of Plastic Surgery: June 2020 - Volume 84 - Issue 6 - p 684-688 doi: 10.1097/SAP.0000000000002262 Buy Metrics Abstract Nerve grafts represent an invaluable tool, when reconstructing nerve defects of more than 1 cm. Historically, the criterion standard use of autografts has relied on the premise of using nonessential sensory nerves to fulfill the principle of replacing “like with like,” while simultaneously minimizing the infliction of undue morbidity on the patient. The reconstructive surgeon thus faces a dilemma when extensive nerve damage requires reconstruction, or when donor nerves are not available or limited such as in the pediatric population. Cadaver nerve grafts (CNG) uniquely allow for reconstruction of large nerve lesions without the presence of host morbidity. The following article reviews the use of CNG, its indications, advantages, and disadvantages, as well as provides some case studies of real-world application. In addition, an insight into the future perspectives of CNG is provided. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.