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Extracorporeal Free Flap Perfusion Using Extracorporeal Membrane Oxygenation Device

An Experimental Model

Ozturk, Muhammed Besir MD*; Aksan, Tolga MD*; Ozcelik, Ismail Bulent MD; Ertekin, Cengiz MD*; Akcakoyunlu, Bahadir PhD; Ozkanli, Sidika Seyma MD§; Tezcan, Mustafa MD*

doi: 10.1097/SAP.0000000000002014
Transplantation Surgery and Research

Extracorporeal perfusion of organs has a wide range of clinical applications like prolonged vital storage of organs, isolated applications of drugs, bridging time to transplant, and free composite tissue transfer without anastomosis, but there are a limited number of experimental models on this topic.

This study aimed to develop and evaluate a human extracorporeal free flap perfusion model using an extracorporeal membrane oxygenation device. Five patients undergoing esthetic abdominoplasty participated in this study. Deep inferior epigastric artery perforator flaps were obtained abdominoplasty flaps, which are normally medical waste, used in this model. Deep inferior epigastric artery perforator flaps were extracorporeally perfused with a mean of 6 days. The biochemical and pathological evaluations of the perfusions were discussed in the article.

From the *Department of Plastic Reconstructive Surgery, and Aesthetic Surgery, Istanbul Medeniyet University, Goztepe Education and Research Hospital

El Istanbul Hand Surgery, Microsurgery, and Rehabilitation Group, Yeniyuzyil University Gaziosmanpasa Hospital

Department of Cardiovascular Surgery, Medicana Bahcelievler Hospital

§Department of Pathology, Goztepe Training and Research Hospital, T.C. Medeniyet University, Istanbul, Turkey.

Received February 2, 2019, and accepted for publication, after revision May 6, 2019.

Conflicts of interest and sources of funding: none declared.

Reprints: Muhammed Besir Ozturk, MD, Department of Plastic Reconstructive and Aesthetic Surgery, Istanbul Medeniyet University, Goztepe Education and Research Hospital, Aksahin sokak Karasahin Apt, No 10/9, Beyoglu, Istanbul, 34445 Turkey. E-mail:

Online date: November 4, 2019

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