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Risk Factors Associated With Postoperative Recurrence in Patients With Tenosynovial Giant Cell Tumor of the Hand

A Retrospective Cohort Study

Shi, Jialu*,†; Zheng, Jingwei MD; Zhou, Xijie MD*; Li, Zhijie MD*; Chen, Xinglong MD*; Gao, Weiyang MD*; Yan, Hede PhD*

doi: 10.1097/SAP.0000000000001983
Hand Surgery

Identification of risk factors for recurrence of tenosynovial giant cell tumors of the hand is crucial to provide adequate preoperative counseling and tailor surgical treatment. However, the risk factors are still controversial, which are the subject of this research.

Recently, we conducted a retrospective cohort study of 135 consecutive patients with giant cell tumors of the tendon sheath of the hand from January 2010 to July 2016. All patients underwent surgical excision, received necessary imaging examinations, and had routine follow-up and thus were identified as those who had recurrence by confirmation of reoperation, and the duration ranged from 24 to 103 months (mean, 53.5 ± 21.4 months). There were 14 local recurrences (10.4%) within 6 to 24 months, respectively, after surgery. Data pertaining to sex, age, tumor sites, tumor size, tumor number, course of disease, bone erosion, tumor growth patterns, anesthesia mode, and the surgeon's experience were all extracted, and Cox regression models were used to estimate recurrence rate with adjustment for potential confounders.

According to the Cox regression analysis, the recurrence rate after surgery was significantly higher in patients with a diffused form than in those with a localized one (P = 0.001); in addition, patients with 2 or more tumors had a much higher postoperative recurrence rate than did those with only 1 tumor (P = 0.023).

This study suggested that the recurrence rate of tenosynovial giant cell tumors of the hand was closely related to the tumor number and tumor growth patterns.

From the *The Second School of Medicine, Wenzhou Medical University

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University

The Eye Hospital of Wenzhou Medical University, Wenzhou, China.

Received March 12, 2019, and accepted for publication, after revision April 15, 2019.

Conflicts of interest and sources of funding: none declared.

Reprints: Hede Yan, MD, PhD, Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 West Xueyuan Rd, Lucheng District, Wenzhou 325027, China. E-mail:

Online date: September 13, 2019

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