Breast SurgeryBreast Reduction Following Hormonal Therapy in a Transgender Female PatientMargulies, Ilana G. MS; Xu, Hope BA; Kozato, Aki BS; Facque, Alexander MD; Taub, Peter J. MD, MS Author Information From the Division of Plastic and Reconstructive Surgery, Icahn School of Medicine at Mount Sinai, New York, NY. Received October 15, 2018, and accepted for publication, after revision December 29, 2018. Conflicts of interest and sources of funding: none declared. I.G.M. and H.X. contributed equally to this study. Reprints: Ilana G. Margulies, MS, 5 East 98th St, Box 1259 New York, NY 10029. E-mail: [email protected]. Annals of Plastic Surgery: October 2019 - Volume 83 - Issue 4 - p 401-403 doi: 10.1097/SAP.0000000000001855 Buy Metrics Abstract In male-to-female gender transition, individuals request a number of interventions, including hormonal therapy, to promote feminizing characteristics. Estrogen-based medication is prescribed to increase breast development, decrease facial hair, promote feminine adipose tissue deposition, and soften skin. Surgical breast augmentation to supplement unsatisfying breast growth after hormonal therapy is a common and well-studied course of management for such transgender patients. In a departure from convention, the authors present a case of symptomatic macromastia requiring surgical breast reduction in a transgender woman following 24 years of hormonal therapy and illicit silicone injections in multiple areas of her body, including the breasts. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.