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Long-Term Characterization of Cranial Defects After Surgical Correction for Single-Suture Craniosynostosis

Skolnick, Gary B., BA*; Murthy, Sindhoora, MD; Patel, Kamlesh B., MD, MSc*; Huang, Zhiyang, BS; Naidoo, Sybill D., PhD, CPNP*; Ju, Tao, PhD; Smyth, Matthew D., MD*; Woo, Albert S., MD§

doi: 10.1097/SAP.0000000000001906
Research
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Introduction Craniosynostosis is typically corrected surgically within the first year of life through cranial vault reconstruction. These procedures often leave open calvarial defects at the time of surgery, which are anticipated to close over time in a large proportion of cases. However, residual calvarial defects may result as long-term sequelae from cranial vault remodeling. When larger defects are present, they may necessitate further reconstruction for closure.

Better understanding of the calvarial osseous healing process may help to identify which defects will resolve or shrink to acceptable size and which will require further surgery. Our study aims to assess the long-term changes in defect size after cranial vault reconstruction for craniosynostosis.

Methods One-year postoperative and long-term computed tomography scans were retrieved from the craniofacial anomalies archive. Analysis used custom software. All defects above the size of 1 cm2 were analyzed and tracked for calvarial location, surface area, and circularity. Monte Carlo simulation was performed to model the effect of initial defect size on the rate of defect closure.

Results We analyzed a total of 74 defects. The mean ± SD initial defect surface area was 3.27 ± 3.40 cm2. The mean ± SD final defect surface area was 1.71 ± 2.54 cm2. The mean ± SD percent decrease was 55.06% ± 28.99%. There was a significant difference in the percentage decrease of defects in the parietal and frontoparietal locations: 68.4% and 43.7%, respectively (P = 0.001). Monte Carlo simulation results suggest that less than 10% of defects above the size of 9 cm2 will close to the size of 2.5 cm2 or less.

Conclusions We describe and make available a novel validated method of measuring cranial defects. We find that the large majority of initial defects greater than 9 cm2 remain at least 1 in2 in size (2.5 cm2) 1 year postoperatively. In addition, there appear to be regional differences in closure rates across the cranium, with frontoparietal defects closing more slowly than those in the parietal region. This information will aid surgeons in the decision-making process regarding cranioplasty after craniosynostosis correction.

From the *Division of Plastic and Reconstructive Surgery, Washington University in St Louis, St Louis, MO;

Department of Internal Medicine, University of Maryland Medical Center, Baltimore, MD;

Department of Computer Science and Engineering, Washington University in St Louis, St Louis, MO; and

§Division of Plastic and Reconstructive Surgery, The Warren Alpert Medical School of Brown University, Providence, RI.

Received April 18, 2017, and accepted for publication, after revision January 29, 2019.

Conflicts of interest and sources of funding: This study was funded AQ8 through the T35 NIH NHLBI Training Grant and the ICTS/CTSA, NIH grant number UL1 TR000448. The authors declare no conflict of interest.

Reprints: Gary B. Skolnick, BA, Division of Plastic and Reconstructive Surgery, Washington University in St Louis, St Louis, MO. E-mail: gskolnic@wustl.edu.

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