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Unfiltered Nanofat Injections Rejuvenate Postburn Scars of Face

Jan, Saadia Nosheen, FRCS*; Bashir, Muhammad Mustehsan, FCPS*; Khan, Farid Ahmad, FCPS*; Hidayat, Zohaib, FCPS*; Ansari, Hamid Hussain, FCPS*; Sohail, Muhammad, FCPS*; Bajwa, Afzaal Bashir, FCPS*; Shami, Hussan Birkhez, MBBS*; Hanif, Asif, PhD; Aziz, Faiza, MS; Choudhery, Mahmood S., PhD

doi: 10.1097/SAP.0000000000001631
Burn Surgery and Research
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The aim of this study was to compare the quality of postburn facial scars before and after injection of unfiltered nanofat. The study was performed in the Plastic Surgery Department of Mayo Hospital, Lahore, Pakistan, from January 2015 to December 2016. Forty-eight patients with postburn facial scars were included; age range was 4 to 32 years with Fitzpatrick skin types between 3 and 4. Patients with hypertrophic scars, contractures, or keloids were excluded. Scars were assessed by a senior plastic surgeon and the patient on the POSAS (Patient Observer Scar Assessment Scale). Fat was harvested from the abdomen and/or thighs with a 3-mm multiport liposuction cannula (containing several sharp side holes of 1 mm) using Coleman technique. The harvested fat was emulsified and transferred into 1-mL Luer-Lock syringes for injection into the subdermal or intradermal plane. Final follow-up was scheduled at 6 months, and scar was rated by the patient and the same surgeon on the POSAS. Preoperative and postoperative scar scores were compared, and P values were calculated. Results indicated that after nanofat grafting, there was a statistically significant improvement in scar quality. The most significant improvements on the observer scale were seen in pigmentation and pliability (P < 0.0001). Thickness and relief were the least improved variables (P = of 0.785 and 0.99, respectively). ImageJ scanning also showed pigmentation change (P = 0.076). A statistically significant improvement was seen in all parameters of the patient section of the POSAS (P < 0.0001). In conclusion, unfiltered nanofat grafting seems to be a promising and effective therapeutic approach in postburn facial scars, showing significant improvement in scar quality. The trial was registered on www.clinicaltrials.gov with following ID NCT03352297.

From the *King Edward Medical University/Mayo Hospital;

Gulab Devi Hospital; and

Tissue Engineering and Regenerative Medicine Laboratory, King Edward Medical University, Lahore, Pakistan.

Received May 18, 2018, and accepted for publication, after revision August 2, 2018.

Conflicts of interest and sources of funding: None declared.

Reprints: Mahmood S. Choudhery, PhD, Tissue Engineering and Regenerative Medicine Laboratory, Department of Biomedical Sciences, King Edward Medical University, Nelagumbad, Anarkali, Lahore, 54000, Pakistan. E-mail: ms20031@yahoo.com; drmahmood@kemu.edu.pk.

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