The process of palatal development is regulated by growth factors, extracellular matrix (ECM) protein, and cell adhesion molecules, of which disturbance may result in cleft palate. Knockout mice are important animal models for studying the role of genes during palatal development. Therefore, in this review, we will describe genes knockout in mice to reveal the biological mechanisms of these genes in the formation of the cleft palate.
From the *Department of Cleft Lip and Palate Surgery, West China Stomatological Hospital, Sichuan University; †State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Received July 24, 2012, and accepted for publication, after revision, April 5, 2013.
Conflicts of interest and sources of funding: This research was supported by the National Natural Science Foundation of China (No. 81070498). No other relevant financial relationships and conflict of interest exist in the work.
Reprints: Qian Zheng, MD, PhD, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14 3rd Section, Renmin South Road, Chengdu, Sichuan Province, China 610041. E-mail: email@example.com.