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Changes in the Blood Flow of the Femoral Artery by Botulinum Toxin A in Rats

Hayashi, Minoru MD; Shimizu, Yuki MD, PhD; Sato, Masahide MD, PhD; Yokoyama, Toshiya MD, PhD; Yosimoto, Shinya MD, PhD

doi: 10.1097/SAP.0b013e31826eabe3
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We examined the changes in blood flow in the femoral artery caused by botulinum toxin A in rats. Blood flow was measured using laser Doppler flowmetry. We used male Sprague-Dawley–derived rats weighing between 350 and 400 g. The study was performed on 6 groups; each of them consisted of 30 rats (control and botulinum toxin A 0.5, 1, 2, 4, and 8 units). The laser Doppler flowmetry revealed that blood flow in the femoral artery increased by the third day in the groups injected with 1 or more units of botulinum toxin A. In the groups injected with 8 units of botulinum toxin A, we recognized an increase of blood flow from the second day. Our results suggest that botulinum toxin A is concerned in improving blood flow.

From the Department of Plastic and Reconstructive Surgery, School of Medicine, Showa University, Tokyo, Japan.

Received April 18, 2012, and accepted for publication, after revision, August 10, 2012.

Conflicts of interest and sources of funding: none declared.

Reprints: Minoru Hayashi, MD, Department of Plastic and Reconstructive Surgery, School of Medicine, Showa University, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, Japan 142-8666. E-mail: mokkox2@yahoo.co.jp.

© 2014 by Lippincott Williams & Wilkins