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Effect of Lidocaine on Reducing Injury in a Rat Electrical Burn Model

Benlier, Erol MD*; Eskiocak, Sevgi MD; Puyan, Fulya Oz MD; Sikar, Emel Yurdakul MD§; Kandulu, Huseyin MD; Omurlu, Imran Kurt MD; Top, Husamettin MD*; Aygit, Ahmet Cemal MD#

doi: 10.1097/SAP.0b013e3182586b2a
Burn Surgery and Research

Electrical injuries induce progressive tissue loss. We evaluated the effect of lidocaine on tissue necrosis after electrical burn injuries. Forty-two male Wistar albino rats (250–300 g) were divided into 3 groups [Group A (n = 6), control group without an electrical burn injury; and Groups B (n = 18) and C (n = 18), electrical burn injury groups without and with lidocaine therapy, respectively]. Three separate analyses were performed at different time points on 6 of 18 rats from Groups B and C at each time point. Electrical burns were induced by applying 220 V AC between the left upper and right lower extremities for 10 seconds. Myeloperoxidase and malondialdehyde levels were measured in skin and muscle biopsy specimens after the first hour, fresh and dry weight differences in the amputated extremities were calculated after 24 hours, and live and necrotic tissue areas were measured at 7 days after burn injury. We found that lidocaine reduced edema, the number of neutrophils, and neutrophil damage in tissues. We conclude that lidocaine decreased the amount of necrotic tissue caused by electric injury.

From the Departments of *Plastic Reconstructive and Aesthetic Surgery, †Biochemistry, and ‡Pathology, Trakya University Faculty of Medicine, Edirne; §Afyonkarahisar Kocatepe State Hospital, Afyonkarahisar; ∥Bilecik State Hospital, Bilecik; ¶Department of Biostatistics, Adnan Menderes University Faculty of Medicine, Aydın; and #Bagcilar Research and Education Hospital, Istanbul, Turkey.

Received August 5, 2011, and accepted for publication, after revision, April 2, 2012.

Presented at the 30th National Congress of Turkish Plastic, Reconstructive and Aesthetic Surgery (E-076, p: 316, Antalya, Turkey, 15–19 October, 2008); and at the 6th Congress of The Balkan Association of Plastic, Reconstructive and Aesthetic Surgery (no. 115, pp. 105–106, Ohrid, Macedonia, June 4–7, 2009).

Conflicts of interest and sources of funding: Supported by Trakya University Scientific Research Project no. 642.

Reprints: Erol Benlier, MD, Department of Plastic Reconstructive and Aesthetic Surgery, Trakya University Faculty of Medicine, 22030 Edirne, Turkey. E-mail:

© 2012 Lippincott Williams & Wilkins, Inc.