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Protective Effect of Human Recombinant Copper–Zinc Superoxide Dismutase on Zone of Stasis Survival in Burns in Rats

Shalom, Avshalom MD; Kramer, Eyal MD; Westreich, Melvyn MD

doi: 10.1097/SAP.0b013e3181fc04e1
Burn Surgery and Research

Superoxide dismutase, acting as a scavenger of oxygen free radicals, has shown mixed results in increasing burn wound survival. Originally, we demonstrated that human recombinant copper–zinc superoxide dismutase (Hr-CuZnSOD) could increase the survival of failing ischemic flaps in a rat model. Because of the possible similar pathophysiology of tissue ischemia in flaps and the zone of stasis in burns, we conducted a later study using 2 groups of rats with standardized intermediate burns, to ascertain whether Hr-CuZnSOD could increase zone of stasis survival in rats. The results showed that postburn Hr-CuZnSOD failed to improve zone of stasis survival in burns. We decided to undertake a new controlled study to ascertain whether there is a protective effect of Hr-CuZnSOD in cases of intermediate burns. We used 2 groups of rats, one of which received prophylactic treatments with Hr-CuZnSOD before the induction of standardized intermediate burns. Results showed that preburn Hr-CuZnSOD also failed to improve zone of stasis survival in burns. Further studies are needed to adequately understand the effect of oxygen free radicals in burn wound pathophysiology and to determine whether Hr-CuZnSOD has a role in the clinical management of burns or should be abandoned.

From the Department of Plastic Surgery, Assaf Harofeh Medical Center, Zerifin, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Received May 30, 2010, and accepted for publication, after revision, September 11, 2010.

There are no sources of support for the work in the form of grants, equipment, drugs, or any combination of these and there are no conflicts of interest.

Reprints: Avshalom Shalom, MD, Department of Plastic Surgery, Assaf Harofeh Medical Center, Zerifin 70300, Israel. E-mail:

© 2011 Lippincott Williams & Wilkins, Inc.