Review ArticleAdipose-Derived Stem Cells for Wound Healing ApplicationsCherubino, Mario MD*; Rubin, J. Peter MD*†‡; Miljkovic, Natasa MD, PhD*; Kelmendi-Doko, Arta MD*; Marra, Kacey G. PhD*†‡Author Information From the *Division of Plastic Surgery, Department of Surgery, University of Pittsburgh, Pittsburgh, PA; †Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA; and ‡Division of Plastic Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA. Received March 3, 2010, and accepted for publication, after revision, May 7, 2010. Reprints: Kacey G. Marra, PhD, Department of Surgery, 1655E Biomedical Science Tower, 200 Lothrop St, University of Pittsburgh, Pittsburgh, PA 15261. E-mail: [email protected]. Annals of Plastic Surgery: February 2011 - Volume 66 - Issue 2 - p 210-215 doi: 10.1097/SAP.0b013e3181e6d06c Buy Metrics Abstract Nonhealing wounds remain a significant challenge for plastic surgeons. More than 600,000 people suffer from venous ulcers and 1.5 to 3 million people are being treated for pressure sores every year in the United States. The use of tissue engineering techniques such as stem-cell therapy and gene therapy to improve wound healing is a promising strategy. Adipose tissue represents a source of cells that may be able to enhance wound healing. Adipose-derived stem cells (ASCs) are adult stem cells that are easily harvested and of great interest for plastic surgeons. Specifically, ASCs secrete angiogenic growth factors that can induce tissue regeneration. This review describes innovative research strategies using ASCs therapies for treatment of chronic, nonhealing wounds. © 2011 Lippincott Williams & Wilkins, Inc.