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Effect of Human Bone Marrow Stromal Cells and Dermal Fibroblasts on Collagen Synthesis and Epithelization

Lee, Chi-Ho MD, PhD*; Han, Seung-Kyu MD, PhD, FEACS; Choi, Won-Il MD; Kim, Woo-Kyung MD, PhD

doi: 10.1097/SAP.0b013e318036aadf
Original Article
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In a previous in vitro study, the authors reported that bone marrow stromal cells (BSCs) have better wound-healing activities than fibroblasts. The purpose of this study was to evaluate the effect of BSCs and fibroblasts on wound-healing activity in vivo. Cultured human BSCs and dermal fibroblasts taken from the same patients were tested to compare collagen synthesis and epithelization in a rat wound model. No-cell-treated animals were used as controls. The BSC group showed the highest collagen level, followed by the fibroblast group, and then the no-cell group (P < 0.05). In addition, the best epithelization was observed in the BSC group. These results demonstrate that BSCs better stimulate wound healing than fibroblasts in vivo and in vitro.

In a rat wound model, application of human bone marrow stromal cells resulted in greater collagen formation and more rapid epithelization than did the application of human fibroblasts from the same source.

From the *Department of Plastic Surgery, Kangwon National University College of Medicine, Choonchun Korea; and the †Department of Plastic Surgery, Korea University College of Medicine, Seoul Korea.

Reprints: Seung-Kyu Han, MD, PhD, FEACS, Department of Plastic Surgery, Korea University Guro Hospital, 97 Guro-Dong, Guro-Ku, Seoul, Korea 152–703. E-mail: pshan@kumc.or.kr.

© 2007 Lippincott Williams & Wilkins, Inc.