Review ArticleWound Healing in Denervated TissueBarker, Allison R. BS, MSE*; Rosson, Gedge D. MD†; Dellon, A Lee MD†‡§∥ Author Information From the *Johns Hopkins University School of Medicine, Baltimore, MD; †Division of Plastic Surgery and ‡Plastic Surgery and Neurosurgery, Johns Hopkins University; §Plastic Surgery, Neurosurgery, and Anatomy, University of Arizona, Tucson, AZ; and the ∥Dellon Institutes for Peripheral Nerve Surgery. Received February 25, 2006, and accepted for publication March 19, 2006. Conflict of Interest Statement: A. Lee Dellon owns Sensory Management, Inc., which manufactures a device he invented, the Pressure-Specified Sensory Device. The terms of this arrangement are being managed by the Johns Hopkins University in accordance with its conflict of interest policies. Reprints: L. Dellon, MD, Suite 370, 3333 North Calvert Street, Baltimore, MD 21218. E-mail: [email protected]. Annals of Plastic Surgery: September 2006 - Volume 57 - Issue 3 - p 339-342 doi: 10.1097/01.sap.0000221465.69826.b7 Buy Metrics Abstract Sacral and trochanteric pressure sores in patients with plegias, and foot ulceration in patients with diabetic neuropathy, are similar because these wounds occur in tissues that do not have normal innervation. While it is recognized that insensitive tissue increases the likelihood of ulceration and recurrence of ulceration, this review attempts to answer the question, Is wound healing impaired in denervated tissue? A review of the scientific literature of the past 35 years demonstrates that all phases of wound healing are impaired in denervated tissue, and these mechanisms are different from those related to one of the underlying diseases, diabetes. Understanding the value of innervation, a goal of wound healing should be to seek strategies that provide reinnervation to these at-risk tissues. © 2006 Lippincott Williams & Wilkins, Inc.