Original ArticleAn Alternative Dressing Material for the Split-Thickness Skin Graft Donor Site: Oxidized Regenerated CelluloseUysal, A Cagri MD*; Alagoz, M Sahin MD†; Orbay, Hakan MD‡; Sensoz, Omer MD‡Author Information From the *Department of Plastic and Reconstructive Surgery Nippon Medical School, Tokyo, Japan; the †Department of Plastic and Reconstructive Surgery Kocaeli University Faculty of Medicine, Izmit, Turkey; and the ‡Department of Plastic and Reconstructive Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey. Received December 20, 2005, and accepted for publication January 21, 2006. Reprints: A. Cagri Uysal, MD, Department of Plastic and Reconstructive Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan. E-mail: [email protected], [email protected]. Annals of Plastic Surgery: July 2006 - Volume 57 - Issue 1 - p 60-64 doi: 10.1097/01.sap.0000208945.12083.59 Buy Metrics AbstractIn Brief The split-thickness skin graft (STSG) donor sites have been treated with various and plenty of dressing techniques and materials. An ideal STSG donor site dressing should have antibacterial, hemostatic, and promoting epidermal healing properties. We have performed a prospective study to evaluate the effect of the oxidized regenerated cellulose on STSG donor site healing. Between January 2002 and January 2005, 40 patients who were operated in any kind of reconstructive operations with STSG donor sites were included in the study. One half of the wound was covered with oxidized regenerated cellulose and the other half of the same wound of the same patient was covered with fine mesh gauze treated with Furacin (nitrofurazone). The patients were grouped into 2 depending on the dressing technique: group I, semiclosed and group II, closed. The wounds were evaluated for healing time, infection, pain perception of the patient, and final esthetic results. The oxidized regenerated cellulose side of the group I was healed in a mean of 6.5 ± 0.51 days; in group II, 5.4 ± 0.50 days (range, 5–6 days). The fine mesh gauze treated with Furacin in group I was healed in a mean of 9.9 ± 0.97 days (range, 8–11 days); in group II, 8.4 ± 0.99 days (range, 7–10 days). There was a statistical significance between the oxidized regenerated cellulose side and the fine mesh gauze side (P < 0.001) in group I and group II separately. The difference between group I and group II was statistically significant in the oxidized regenerated cellulose side (P < 0.001), and the difference between group I and group II was statistically significant in the fine mesh gauze side (P < 0.005). The antibacterial, hemostatic, and absorbable property of the oxidized regenerated cellulose could ensure the utilization as an alternative STSG donor site dressing, especially because the positive influence over the wound healing was proven. A 40-patient comparison study of topical oxidized regenerated cellulose (ORC) versus Furacin gauze in the healing of skin graft donor sites demonstrated significantly earlier completion of epithelization in the ORC group. © 2006 Lippincott Williams & Wilkins, Inc.