Original ArticleThe Effects of Varying Degrees of Pressure Delivered by Negative-Pressure Wound Therapy on Skin PerfusionTimmers, M S.*; Le Cessie, S PhD†; Banwell, P FRCS(Plast)‡; Jukema, G N. MD, PhD*Author Information From the *Section of Traumatology, Department of Surgery and †Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands; and the ‡Odstock Centre for Burns, Plastic & Reconstructive Surgery, Salisbury District Hospital, Salisbury, UK.. Received July 16, 2005, and accepted for publication, after revision, August 26, 2005. Supported by a research grant from Kinetic Concepts Inc., San Antonio, TX. Reprints: G. N. Jukema, MD, PhD, Head Section of Traumatology, Department of Surgery, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. E-mail: [email protected]. Annals of Plastic Surgery: December 2005 - Volume 55 - Issue 6 - p 665-671 doi: 10.1097/01.sap.0000187182.90907.3d Buy Metrics AbstractIn Brief Vacuum-assisted closure (V.A.C. Therapy) uses 2 distinct types of foams, with different physical characteristics: the black polyurethane (PU) foam and the white polyvinyl alcohol (PVA) foam. This prospective, randomized study evaluates the response of cutaneous blood flow (CBF) in healthy intact forearm skin to varying V.A.C. Therapy negative pressures and both foam types. Continuous negative pressure was used in the range of 25–500 mm Hg. Skin blood flow was measured with noninvasive laser Doppler probes incorporated into the foam. Significant increase in CBF was found with both foams up to negative pressure of 300 mm Hg, with over 5-fold increase (mean: 5.57; SD: 3.32) with the PU foam and nearly 3-fold increase (mean: 2.87; SD: 1.29) with the PVA foam. Comparison of blood flow at baseline and at a negative pressure of 300 mm Hg showed a statistically significant difference (P < 0.001). No decrease in blood flow below baseline was observed during the experiments. A prospective randomized study comparing the 2 VAC foam types demonstrated that the increase in skin blood flow beneath the black polyurethane foam was 67% greater than that beneath the white polyvinyl alcohol foam at b300 mm Hg. Copyright © 2005 Wolters Kluwer Health, Inc. All rights reserved.