Original ArticlePrevention of Peritendinous Adhesions Following Flexor Tendon Injury With SeprafilmMenderes, Adnan MD; Mola, Fahri MD; Tayfur, Volkan MD; Vayvada, Haluk MD; Barutçu, AliAuthor Information From the Dokuz Eylul University, Faculty of Medicine, Department of Plastic, Reconstructive and Aesthetic Surgery, Izmir, Turkey. Received December 22, 2003 and accepted for publication, after revision, April 23, 2004. Reprints: Volkan Tayfur, MD, Dokuz Eylul Uni, Tip Fak, Plastik Cerrahi, Inciralti, Izmir, 35340 Turkey. E-mail: [email protected] Annals of Plastic Surgery: December 2004 - Volume 53 - Issue 6 - p 560-564 doi: 10.1097/01.sap.0000134507.00053.1a Buy Metrics AbstractIn Brief Peritendinous adhesions are the most important complication of flexor tendon injury. In this study, Seprafilm was used for the prevention of peritendinous adhesions following flexor tendon repair. Seprafilm Bioresorbable Membrane (Genzyme Corporation, Cambridge, MA) contains sodium hyaluronate and carboxymethyl cellulose. Thirty New Zealand white male rabbits were divided equally into 3 groups. In all groups, the deep flexor tendon of the third finger of the left back foot was cut and repaired by Kessler-Tajima suture technique. In the first study group following tendon repair, Seprafilm was wrapped around the repaired tendon. In the second study group, sodium hyaluronate gel was injected to the operation field after tendon repair. In the control group, no external material was applied to the field. The study groups had better range of motion. Histopathologically, study groups had less adhesions compared with the control groups. As a result, it was concluded that in rabbit the peritendinous adhesions following flexor tendon repairs could be lowered with Seprafilm and hyaluronic acid. In a rabbit hindfoot model, third-finger flexor tendon transection and repair was performed (1) wrapping the repair with Seprafillm, (2) injecting the field with sodium hyaluronate gel, or (3) no additional treatment. Both the first 2 groups healed with better range of motion and fewer adhesions than the untreated repairs. © 2004 Lippincott Williams & Wilkins, Inc.