Original ArticlesHomologous Collagen Dispersion (Dermalogen) as a Dermal Filler: Persistence and Histology Compared With Bovine CollagenSclafani, Anthony P. MD*†; Romo, Thomas III MD*†; Parker, Andrew MD†; McCormick, Steven A. MD†‡; Cocker, Rubina MD‡; Jacono, Andrew MD† Author Information *Division of Facial Plastic & Reconstructive Surgery, The New York Eye & Ear Infirmary, New York; the Department of Otolaryngology Head & Neck Surgery, New York Medical College, Valhalla; the †Department of Otolaryngology Head & Neck Surgery, The New York Eye & Ear Infirmary, New York; and the ‡Department of Pathology, The New York Eye & Ear Infirmary, New York, NY. Received Aug 14, 2001, and in revised form Nov 27, 2001. Accepted for publication Nov 27, 2001. Address correspondence and reprint requests to Dr Sclafani, Division of Facial Plastic Surgery, The New York Eye & Ear Infirmary, 310 East 14th Street, 6th Floor, North Building, New York, NY 10003. Sclafani AP, Romo III T, Parker A, McCormick SA, Cocker R, Jacono A. Homologous collagen dispersion (Dermalogen) as a dermal filler: persistence and histology compared with bovine collagen. Annals of Plastic Surgery: August 2002 - Volume 49 - Issue 2 - p 181-188 Buy Abstract To assess the biological behavior and clinical efficacy of homologous collagen dispersion (Dermalogen) in augmenting human dermis, Dermalogen and bovine cross-linked collagen (Zyplast) were compared in a human postauricular injection model. Dermalogen (two sites implanted behind one ear) and Zyplast (two sites behind the contralateral ear) were injected into an upper to middermal level in 20 healthy adults. Digital photographs of all implant sites were taken over a 12-week period after injection. Biopsies of each implant type were taken at 4 and 12 weeks after injection. At 12 weeks after injection there was a small but significant difference in persistence rates between Dermalogen and Zyplast (4% vs. 2%;p = 0.005). Histologically, Dermalogen was identifiable at 4 weeks after implantation, with evidence of neovascularization. Zyplast was identified more uniformly than Dermalogen in specimens 12 weeks after implantation, and more chronic inflammatory cells and foreign body giant cells were seen in the Dermalogen specimen. Clinical persistence and the histological behavior of Dermalogen appears to be at least as favorable as Zyplast bovine collagen. Dermalogen does not require pretesting and can also be used in the patient already sensitized to bovine protein. For these reasons, the authors think Dermalogen is a reasonable alternative to bovine collagen for facial soft-tissue augmentation. © 2002 Lippincott Williams & Wilkins, Inc.