Accelerated Maturation in Prefabricated Flaps by Transforming Growth Factor-β

An Experimental Study in the Rabbit

Abstract

 

We evaluated whether application of transforming growth factor-β (TGF-β) during the first operation could shorten the interval required before creating a neovascularized flap in rabbits. Central ear vessels were transferred under the skin. After different time intervals, the flaps were raised as an island flap. In the group receiving TGF-β, flap survival was 94% of initial length, whereas the control group reached 49% of initial length 3 days later. Five days later, flap survival was 98% in the TGF-β group and the control group reached 78%. Histological examination revealed prominent angioneogenesis surrounding implanted vessels in the rabbits receiving TGF-β. This suggests that TGF-β may accelerate flap maturation.

Iwasawa M. Accelerated maturation in prefabricated flaps by transforming growth factor-β: an experimental study in the rabbit. Ann Plast Surg 1993;31:72-75