Original Article: PDF OnlyEfficacy of Verapamil in the Salvage of Failing Random Skin FlapsNichter, Larry S. M.D; Sobieski, Michael W. B.A.Author Information University of Southern California School of Medicine, Division of Plastic and Reconstructive Surgery, Los Angeles, CA. Annals of Plastic Surgery: September 1988 - Volume 21 - Issue 3 - p 242-245 Buy Abstract Verapamil is a calcium channel blocker that inhibits mast cell degranulation, platelet aggregation, and neutrophil function and is a potent vasodilator. The efficacy of verapamil (20 mg/kg/day) to salvage a standard failing random skin flap in the rat was studied. In this study verapamil failed to benefit skin flap survival. The results are analyzed and presented. © Williams & Wilkins 1988. All Rights Reserved.