In Brief:
Controversy still exists concerning the optimal site for an esophagogastric anastomosis. This trial compares in a prospective randomized fashion two types of esophagogastric anastomosis: one in the neck and the other in the right chest. We conclude that neck and chest anastomoses after esophageal resection are equally safe and provide equal morbidity, mortality, anastomotic diameter, body weight development, and long-term survival.