The TME Trial After a Median Follow-up of 6 Years: Increased Local Control But No Survival Benefit in Irradiated Patients With Resectable Rectal Carcinoma Peeters, Koen C.M.J.; Marijnen, Corrie A.M.; Nagtegaal, Iris D.; More Peeters, Koen C.M.J.; Marijnen, Corrie A.M.; Nagtegaal, Iris D.; Kranenbarg, Elma Klein; Putter, Hein; Wiggers, Theo; Rutten, Harm; Pahlman, Lars; Glimelius, Bengt; Leer, Jan Willem; van de Velde, Cornelis J.H.; for the Dutch Colorectal Cancer Group Less Annals of Surgery. 246(5):693-701, November 2007. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The TME trial, a randomized controlled trial investigated the efficacy of preoperative short-term radiotherapy in patients with rectal cancer treated with TME surgery. After a median follow-up of 6 years, there is still a significant effect of radiotherapy on local recurrence rate, there is however no effect on overall survival.