Colorectal liver metastases are considered a contraindication for liver transplantation. In this study, liver transplantation for nonresectable colorectal liver metastases was performed (n = 21). Five-year survival rate post–liver transplantation was 60% (95% confidence interval, 34–85). Relapse was frequent, but many patients with recurrence were available for surgery. At follow-up, 33% had no evidence of disease.