*Division of General Surgery, Department of Surgery, University of Ottawa, Ottawa, Canada
†Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada
‡Division of Critical Care, University of Ottawa, Ottawa, Canada
§Department of Critical Care, Lakeridge Health Corporation, Oshawa, Ontario, Canada
∥Carilion Clinic, Virginia Tech Carilion School of Medicine, Roanoke, VA
¶Department of Pharmacy Services, UC Health - University of Cincinnati Medical Center, Cincinnati, OH
#Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Canada
**Division of Acute Care Surgery, Department of Surgery, University of Southern California, Los Angeles, CA, USA
††Division of Acute Care Surgery, Departments of Surgery, Anesthesiology and Critical Care, Emergency Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD
‡‡Department of Health Policy and Management, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
§§Red Duke Trauma Institute, Memorial Hermann Hospital, Houston, TX
∥∥Department of Surgery, Robert Wood Johnson University Hospital, New Brunswick, NJ
¶¶Division of General Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada
##Division of Critical Care, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
***Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada
A.T., S.M.F., and B.R. conceived the study idea and designed the protocol. A.T. and S.M.F. completed the search and data extraction. R.S.G., J.R.G., and M.E.D. provided primary data from observational cohorts. A.T. completed data analysis. All authors interpreted the study findings. A.T. drafted the initial manuscript. All authors participated in revision of the manuscript and approved its submission.
M.C. is supported by a Tier 2 Research Chair in Venous Thrombosis and Cancer from the Department of Medicine at the University of Ottawa. M.C. reports research funding from Leo Pharma, Pfizer, and Bristol-Myers Squibb and honoraria from Pfizer, Bayer, Bristol-Myers Squibb, Sanofi, Leo Pharma, and Servier. B.R. is supported by a McMaster Department of Medicine Mid-Career Award. The remaining authors report no conflicts of interest.
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