∗University of Washington, Harborview Medical Center, Seattle, Washington
†Atrium Health, Charlotte, North Carolina
‡Ohio Health, Grant & Mansfield Hospitals, Columbus, Ohio
§University of Maryland, Baltimore, Maryland
¶Carolinas Medical Center, Charlotte, North Carolina
||East Carolina University, Greenville, North Carolina
∗∗University of Pittsburgh, Pittsburgh, Pennsylvania
††Massachusetts General Hospital, Boston, Massachusetts
‡‡University of Pennsylvania, Philadelphia, Pennsylvania
§§Atox Bio Ltd, Durham, North Carolina
¶¶Biomedical Statistical Consulting, Wynnewood, Pennsylvania
||||University of Kentucky, Lexington, Kentucky.
∗∗∗The ACCUTE study investigators represent the 93 study sites in the US and France, please see Investigator List. ACCUTE: AB103 Clinical Composite Endpoint Study in Necrotizing Soft Tissue Infections Clinicaltrials.gov: NCT02469857.
[email protected].
This project has been funded in part with Federal funds from the Department of Health and Human Services, Office of the Assistant Secretary for Preparedness and Response, Biomedical Advanced Research, and Development Authority, under Contract No. HHSO100201400013C. Additional Funding was from Atox Bio Ltd.
Disclosure: E. M. Bulger, None. A. K. May, Atox Bio Ltd Role(s): Consulting, Membership on advisory committee or review panels, Blinded adjudication panel for trial. B. R. Robinson, None. D. C. Evans, Atox Bio Ltd Role(s): Membership on advisory committee or review panels, Blinded adjudication panel for trial. S. Henry, None. J. M. Green, None. E. Toschlog, None. J. L. Sperry, None. P. Fagenholz, None. N. D. Martin, None. W. M. Dankner, Atox Bio Ltd Role(s): Employment. G. Maislin, Atox Bio Ltd Role(s): Independent contractor (including contracted research), Study Statistician. D. Wilfret, Atox Bio Ltd Role(s): Employment. A. C. Bernard, Atox Bio Ltd Role(s): Membership on advisory committee or review panels, Blinded adjudication panel member.
The authors have no other conflicts of interests to disclose.
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.annalsofsurgery.com).
Author Contributions: Substantial contributions to conception and design of the trial: EB, AM, DE, WD, GM, DW.
Substantial contributions to acquisition of data: EM, BR, DC, SH, JG, ET, JS, PF, NM, WD, DW, AB.
Substantial contributions to analysis of data: EB, AM, DE, WD, GM, AB.
Drafting of the article: EB, GM.
Critical Revision of the article: AM, BR, DE, SH, JG, ET, JS, PF, NM, WD, DW, AB.
Accute Study Investigators: ACCUTE Trial Contributing Hospitals and Investigators, alphabetical by state or province. United States: Alabama: Birmingham: University of Alabama at Birmingham Hospital, Ross Vander Noot, MD; Arizona: Phoenix: Maricopa Medical Center, Kevin Foster, MD; Tucson: Banner University Medical Center, Bellal Joseph, MD; Arkansas: Little Rock: University of Arkansas for Medical Sciences, Kevin Sexton, MD; California: Davis: University of California Davis Medical Center, Christine Cocanour, MD; Irvine: University of California, Irvine Medical Center, Michael Lekawa, MD; Loma Linda: Loma Linda University Medical Center, Richard Catalano, MD; Los Angeles: Harbor UCLA Medical Center, Dennis Kim, MD; Keck Hospital of USC, Kazuhide Matsushima, MD; LAC+USC Medical Center, Demetrios Demetriades, MD; San Diego: University of California, San Diego Medical Center, Leslie Kobayashi, MD; Colorado: Colorado Springs: UCH-Memorial Hospital System, Thomas Schroeppel, MD; Denver: University of Colorado Hospital, Robert McIntyre, MD; Denver Health Medical Center, Eric Campion, MD; Connecticut: Yale New Haven Hospital, Adrian Maung, MD; Delaware: Newark: Christiana Care Health System, Luis Cardenas, MD; District of Columbia: Washington Hospital Center, Jack Sava, MD; Florida: University of Florida Health Shands Hospital, Scott Brakenridge, MD; Ryder Trauma/Jackson Memorial Hospital, Nicholas Namias, MD; Georgia: Atlanta: Emory University at Grady Memorial Hospital, Rondi Gelbard, MD; Augusta: Augusta University Health, Lester Young, MD; Joseph M Still Burn Center at Doctors Hospital, Bounthavy Homsombath, MD; Illinois: Maywood: Loyola University Medical Center, Michael Mosier, MD; Indiana: Indianapolis: Indiana University Health Methodist Hospital, Robert Reed, MD; Iowa: Iowa City: University of Iowa Hospital and Clinics, Kent Choi, MD; Kentucky: Lexington: University of Kentucky, Andrew Bernard, MD; Louisville; University of Louisville, Brian Harbrecht, MD; Louisiana: Baton Rouge: Baton Rouge General Hospital and Our Lady of the Lake Regional Medical Center, Hollis O’Neal, MD; New Orleans: LSU Health Science Center, Patrick Greiffenstein, MD; Maine: Portland: Maine Medical Center, Joseph Rappold, MD; Maryland: Baltimore: University of Maryland Medical R Adams Cowley Shock Trauma Center, Sharon Henry, MD; Massachusetts: Boston: Brigham and Women's Hospital, Reza Askari, MD; Massachusetts General Hospital, Peter Fagenholz, MD; Boston Medical Center, Peter Burke, MD; Michigan: Ann Arbor: University of Michigan, Pauline Park, MD; Detroit: Henry Ford Hospital System, Jeffrey Johnson, MD; Wayne State University-Sinai Grace Hospital, Robert Sherwin, MD; Wayne State University-Detroit Receiving Hospital, Larry Diebel, MD; Minnesota: Edina: Fairview Southdale Hospital, Julie Ottosen, MD; Minneapolis: University of Minnesota Medical Center-Fairview, Julie Ottosen, MD; Hennepin County Medical Center, Frederick Endorf, MD; Saint Paul: HealthPartners Institute, David Dries, MD; Missouri: Columbia: University of Missouri, Jacob Quick, MD; St Louis: St. Louis University, Carl Freeman, MD; New Jersey: Camden: Cooper University Hospital, Ju Lin Wang, MD; Trenton: Capital Health System, Inc, Michael Kalina, MD; New Mexico: Albuquerque: University of New Mexico Hospital, Howard Yonas, MD; New York: Albany: Albany Medical Center, Marcel Tafen, MD; Buffalo: Erie Country Medical Center-Affiliate of SUNY at Buffalo, William Flynn, MD; New York: Montefiore Medical Center-Moses Division and Weiler Division, Vance Smith, MD; New York: Staten Island University Hospital-Northwell Health, Stephen Cohn, MD; North Carolina: Charlotte: Atrium Health Carolinas Medical Center, John Green, MD; Durham: Duke University Medical Center, Mark Shapiro, MD; Greenville: East Carolina University Vidant Medical Center, Eric Toschlog, MD; Ohio: Cincinnati: University of Cincinnati Medical Center, Timothy Pritts, MD; Cleveland: The MetroHealth System, Jeffrey Claridge, MD; Columbus: The Ohio State University, David Evans, MD; Dayton: Wright State University and Premier Health Clinical Trials Research Alliance, Peter Ekeh, MD; Toledo: University of Toledo Medical Center, Munier Nazzal, MD; Youngstown: St. Elizabeth Youngstown Hospital, Gregory Huang, MD; Oklahoma: Oklahoma City: Oklahoma University Health Science Center, Jason Lees, MD; Oregon: Portland: Legacy Emanuel Hospital, Elizabeth Windell, MD; Oregon Health and Science University, Martin Schreiber, MD; Pennsylvania: Bethlehem: St. Luke's University Health Network, John Lukaszcyk, MD; Hershey: The Pennsylvania State University and The Milton S. Hershey Medical Center, Melissa Boltz, MD; Philadelphia: The Trauma Center at PENN, Niels Martin, MD; Thomas Jefferson University Hospital, Joshua Marks, MD; Pittsburgh: University of Pittsburgh Medical Center, Jason Sperry, MD; Tennessee: Nashville: Vanderbilt University Medical Center, Addison May, MD; Texas: Dallas: UT Southwestern Medical Center, Joseph Minei, MD; El Paso: Texas Tech University Health Sciences Center at El Paso, Brian Davis, MD; Fort Worth: John Peter Smith Health Network, Rajesh Gandhi, MD; Houston: Baylor College of Medicine-Ben Taub Hospital, Stephanie Gordy, MD; Houston Methodist Hospital, Daniel Bonville, MD; San Antonio: University of Texas Health Science Center at San Antonio, Christopher Crane, MD; Temple: Scott and White Medical Center, Justin Regner, MD; Virginia: Richmond: VCU Medical Center, Paula Ferrada, MD; Washington: Seattle: Harborview Medical Center, Bryce Robinson, MD; Wisconsin: Milwaukee: Medical College of Wisconsin-Froedtert Hospital, Todd Neideen, MD.
France: Clermont-Ferrand: Hopital Estaing-CHU de Clermont-Ferrand, Pr. Jean-Michel Constantin; Creteil: Hopital Henri Mondor, Dr. Nicolas De Prost; Le Kremlin-Bicetre: Hopital Bicetre, Pr Christian Richard; Lille: Robert Salengro Hopital-CHRU Lille, Pr. Daniel Mathieu; Limoges: CHU de Limoges, Dr. Thomas Lafon; Lyon: Hopital Edouard Herriot, Dr Baptiste Hengy; Nancy: CHRU Nancy, Hopital Central, Pr Sebastien Gibot; Nimes: CHU de Nimes, Pr. Jean-Yves LeFrant; Orleans: Hopital de la Source, CHR Orleans, Dr Thierry Boulain; Tours: CHRU Bretonneau, Dr. Emmanuelle Mercier.
