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A Reassessment of Needs and Practice Patterns in Pharmacologic Prophylaxis of Venous Thromboembolism Following Elective Major Surgery

Qadan, Motaz MD, PhD*; Polk, Hiram C. Jr MD*; Hohmann, Samuel F. PhD; Fry, Donald E. MD

doi: 10.1097/SLA.0b013e3181f6fe09
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Venous thromboembolism rates ranged from 0.6-3.2% and pulmonary embolism rates ranged from 0.28%-1.09%. Use of pharmacologic prophylaxis generally increased between 2003/4 and 2007/8. Venous thromboembolism rates, however, were not significantly affected among patients who received pharmacologic prophylaxis, and actually decreased among patients who did not receive any pharmacologic prophylaxis.

* The Price Institute of Surgical Research and Department of Surgery, University of Louisville, School of Medicine, Louisville, KY

University HealthSystem Consortium, Oak Brook, IL; and

Michael Pine and Associates, Chicago, IL.

Dr Qadan holds the Joint Royal College of Surgeons of Edinburgh (RCSEd)/James and Emmeline Ferguson Research Fellowship.

All authors have seen and approved the final manuscript. There were no competing interests to declare by any of the authors. All authors had full access to all the data and all authors had final responsibility for the decision to submit the manuscript for publication. No writing assistance was provided. Data analysis was carried out by M.Q., H.C.P., and S.H. This work was funded in part by the Joint Royal College of Surgeons of Edinburgh (RCSEd)/James and Emmeline Ferguson Research Fellowship Trust. The funding source had no role in the production of the manuscript. The undersigned hereby attest to the above statement and that they have fulfilled the authorship criteria of the uniform requirements.

Reprints: Hiram C. Polk, Jr, MD, Department of Surgery, University of Louisville, School of Medicine, Louisville, KY 40292. E-mail: hcpolk01@louisville.edu.

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