*Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA
†NanoMosaic Inc., Woburn, MA
‡Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA
§Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA
∥Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA
¶Anesthesia and Brain Research Institute, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, P. R. China
#Department of Medicine, Divisions of General Medicine and Gerontology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA
Justification of authorship: All authors made substantial contributions to conception and design, and/or acquisition of data, and/or analysis and interpretation of data; participated in drafting the article or revising it critically for important intellectual content; and gave final approval of the version to be published. The following is the contribution of each author.
Z.X., Q.Q., F.L., Y.S., O.A., B.M.W., J.W.-K., and E.R.M.: Study concept and design. F.L., K.B., A.K., S.-H.C.: acquisition of data. F.L., K.B., K.C., E.R.M., and Z.X.: analysis and interpretation of data. Z.X., Q.Q., and F.L.: drafting of the manuscript. Z.X., Y.S., O.A., B.M.W., J.W.-K., and E.R.M.: critical revision of the manuscript for important intellectual content. Z.X.: obtained funding. Z.X., Y.S., K.B., and S.-H.C.: administrative, technical, and material support. Z.X.: study supervision.
This research was supported by R21 HD098754, R01 AG062509, and RF1 AG070761 from the National Institutes of Health, Bethesda, MD, the research fund from Department of Anesthesia, Critical Care and Pain Medicine at Massachusetts General Hospital and Harvard Medical to support Anesthesia Biomarker Core, and Henry L. Beecher Professorship from Harvard University to Zhongcong Xie.
Disclosure statement: The authors do not have equity interests and patent-licensing arrangements related to the present study. The authors declare no competing or conflict interests to disclose for the present study. Dr Qimin Quan is an employee of NanoMosaic but was not involved in data acquisition, analysis, and interpretation of the present study. Dr Zhongcong Xie provided consulting services to Shanghai 9th and 10th hospitals, and Baxter (invited speaker) in the last 36 months.
The authors report no conflicts of interest.
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