*Department of Surgery, University of Alberta, Edmonton, Canada
†Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
‡CHRISTUS-LatAm Hub - Excellence and Innovation Center, Monterrey, Mexico
§Clinical Islet Transplant Program, University of Alberta, Edmonton, Canada
∥Division of Endocrinology and Metabolism, Department of Medicine, University of Alberta, Edmonton, Canada
¶Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico
#Histocompatibility Laboratory, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
**Alberta Diabetes Institute, Edmonton, Canada
David Bigam and A.M. James Shapiro: Denotes shared co-senior authorship
Authorship page: BAMG contributed to study design, data retrieval and data verification, data analysis and interpretation, figure conception, design and construction, and writing of the report. KV contributed to data retrieval, data verification, data interpretation, and writing of the report. JH contributed to data retrieval, data verification, data interpretation and writing of the report. AL contributed to patient follow-up, data retrieval, and writing of the report. KD contributed to organ procurement, patient care and follow-up, and writing of the report. BA contributed to organ procurement, patient care and follow-up, and writing of the report. DOG contributed to islet isolation, data retrieval and writing of the report. TK contributed to islet isolation, data retrieval, data verification, and writing of the report. OYBC contributed to data analysis and interpretation, figure design and construction, and writing of the report. DG, AH, and PMC contributed to providing data on HLA typing and writing of the report. PAS contributed to patient follow-up, data retrieval, data interpretation and writing of the report. DB contributed to organ procurement, study design, patient care and follow-up, data retrieval, data verification, data interpretation and writing of the report. AMJS contributed to organ procurement, study design, patient care and follow-up, data retrieval, data verification, data interpretation and writing of the report. BAMG, KV, JH, TK, DB and AMJS had access to raw data. DB and AMJS had final responsibility for the decision to submit this manuscript for publication, Supplemental Digital Content 1, https://links.lww.com/SLA/E392.
Abbreviations: CI, confidence interval; ESRD, end-stage renal disease; HR, hazard ratio; IAK, islet-after-kidney transplant; IEQ, islet equivalent; IQR, interquartile range; IRR, incidence rate ratio; ITA, islet transplant alone; ITx, islet transplantation; PAK, pancreas-after-kidney transplant; PTA, pancreas transplant alone; PTx, whole pancreas transplantation; SHE, severe hypoglycemic episode; SIK, simultaneous islet-kidney transplant; SPK, simultaneous pancreas-kidney transplant
Data access statement: All data are available upon reasonable request.
Declaration of interests: There are no relevant conflicts of interest related to the current study. BAMG is a co-inventor for a patent on TNFRSF25-mediated treatments of immune diseases and disorders (PCT/US2020/053085). PAS serves in an independent data monitoring committee overseeing safety of stem cell-derived β-cells for T1D (Vertex Pharmaceuticals), as Board Chair for Diabetes Canada, and as a co-lead for Diabetes Action Canada’s innovations in T1D goal group. AMJS has received grants or contracts from the Juvenile Diabetes Research Foundation, Canadian Stem Cell Network, Diabetes Research Foundation in Canada, ViaCyte Inc., and the National Institutes of Diabetes and Digestive and Kidney Diseases. AMJS serves as a consultant to Protokinetix Inc., ViaCyte Inc., Hemostemix Inc., Diagon Inc., and Aspect Biosystems Inc. AMJS is a co-inventor for a patent on TNFRSF25-mediated treatments of immune diseases and disorders (PCT/US2020/053085) and for a Cellular Transplant Site- Device-less technology (US 14/863541, CA.286512)
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