*Vascular Biology Program, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA
†Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA
‡Institutional Centers for Clinical and Translational Research, Boston Children’s Hospital, Boston, MA, USA
§Alcresta Therapeutics, Newton, MA, USA
∥Animal Care Resources Children’s Hospital, Boston Children’s Hospital, Boston, MA, USA
¶Department of Pharmacy and the Division of Gastroenterology and Nutrition, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA
Author Contributions: Savas T Tsikis: Conceptualization, Data curation, Methodology, Roles/Writing-original draft, Writing-review & editing. Scott C Fligor: Data curation, Methodology, Roles/Writing-original draft, Writing-review & editing. Thomas I Hirsch: Data curation, Methodology, Roles/Writing-original draft, Writing-review & editing. Paul Mitchell: Formal analysis, Validation, Roles/Writing-original draft, Writing-review & editing. Amy Pan: Data curation, Methodology, Roles/Writing-original draft, Writing-review & editing. Kamila Moskowitzova: Data curation, Methodology, Roles/Writing-original draft, Writing-review & editing. Ashlyn Whitlock: Data curation, Methodology, Roles/Writing-original draft, Writing-review & editing. Greta Loring: Conceptualization, Investigation, Methodology, Resources, Roles/Writing-original draft, Writing-review & editing. Eric First: Conceptualization, Investigation, Methodology, Resources, Roles/Writing-original draft, Writing-review & editing. Arthur P Nedder: Project administration, Resources, Supervision, Roles/Writing-original draft, Writing-review & editing. Kathleen M Gura: Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Supervision, Roles/Writing-original draft, Writing-review & editing. Mark Puder: Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Supervision, Roles/Writing-original draft, Writing-review & editing.
Reprints: They will not be available from the authors.
Funding Statement: This project was supported by Alcresta Therapeutics Inc. (Newton, MA), National Institutes of Health 2T32DK007754-22 (STT), and 5T32HL007734 (SCF, TIH), The Boston Children’s Vascular Biology Program, and The Boston Children’s Hospital Surgical Foundation. Alcresta Therapeutics assisted in the design of this study and reviewed the final manuscript but did not have direct involvement in data collection, analysis, interpretation, or the decision to submit the article for publication.
Data Sharing Statement: All data, analytic methods, and information on study materials will be made available to other researchers at reasonable request to the corresponding author.
Conflicts of Interest: Dr. Puder and Dr. Gura receive research support and advisory compensation from Alcresta Therapeutics, Inc (Newton, MA). Dr. Loring and Dr. First were employees of Alcresta Therapeutics, Inc at the time of the study. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript.
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