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Impact of Surgical Treatment for Recurrence After 2-Stage Hepatectomy for Colorectal Liver Metastases, on Patient Outcome

Imai, Katsunori, MD, PhD*,†,¶; Benitez, Carlos Castro, MD*,†,§; Allard, Marc-Antoine, MD*,†,§; Vibert, Eric, MD, PhD*,‡,§; Cunha, Antonio Sa, MD*,†,§; Cherqui, Daniel, MD*,‡,§; Castaing, Denis, MD*,‡,§; Bismuth, Henri, MD, PhD*; Baba, Hideo, MD, PhD; Adam, René, MD, PhD*,†,§

doi: 10.1097/SLA.0000000000002472

Objective: To evaluate the impact of repeat surgery for recurrence on the long-term survival after 2-stage hepatectomy (TSH) for extensive colorectal liver metastases (CRLM).

Background: Although TSH is now deemed effective for selected patients with extensive bilobar CRLM, disease recurrence after TSH is very frequent because of the extensive tumor load.

Methods: Among a total cohort of 1235 patients who underwent hepatectomy for CRLM between 1992 and 2012, 139 with extensive bilobar CRLM were scheduled for TSH. Of these, 93 patients had completion of TSH and were enrolled in this study.

Results: The 5-year overall survival (OS) rate after TSH was 41.3%. Twenty-two patients (23.7%) had a concomitant extrahepatic disease (EHD), and curative resection of concomitant EHD was achieved in 13 patients. Among the 81 patients who achieved complete tumor removal for primary, CRLM, and concomitant EHD, 62 (76.5%) had recurrence. Repeat surgery was performed in 38 patients; 35 for recurrence after curative surgery and 3 for liver recurrence with unresected concomitant EHD or primary tumor. Of these 38 patients, 31 were salvaged. The patients who underwent repeat surgery had a significantly longer OS than those who did not (45.8% vs 26.3%; P = 0.0041). A multivariate analysis revealed that repeat surgery was an independent prognostic factor of the OS after TSH (hazard ratio 0.31, P = 0.0012).

Conclusions: Repeat surgery for recurrence after TSH may be crucial for the long-term survival in patients with extensive bilobar CRLM. Intensive oncosurgical surveillance is essential to avoid missing the chance for repeat surgery after TSH.

*Centre Hépato-Biliaire, AP-HP, Hôpital Universitaire Paul Brousse, Villejuif, France

Inserm, Unité 935, Villejuif, France

Inserm Unité 785, Villejuif, France

§Université Paris-Sud, Villejuif, France

Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan.

Reprints: René Adam, MD, PhD. Centre Hépato-Biliaire AP-HP, Hôpital Paul Brousse, 12 Avenue Paul Vaillant Couturier, F-94804 Villejuif, France. E-mail:

The authors have no conflict of interest to declare.

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