Secondary Logo

Institutional members access full text with Ovid®

Failure-to-rescue in Patients Undergoing Pancreatectomy

Is Hospital Volume a Standard for Quality Improvement Programs? Nationwide Analysis of 12,333 Patients

El Amrani, Mehdi, MD*,†; Clement, Guillaume, MD†,‡; Lenne, Xavier, MSc†,‡; Farges, Olivier, MD, PhD§; Delpero, Jean-Robert, MD, PhD; Theis, Didier, MD†,‡; Pruvot, François-René, MD, PhD*,†; Truant, Stéphanie, MD, PhD*,†

doi: 10.1097/SLA.0000000000002945

Objective: To evaluate the influence of hospital volume on failure-to-rescue (FTR) after pancreatectomy in France.

Background: There are growing evidences that FTR is an important source of postoperative mortality (POM) after pancreatectomy. However, few studies have analyzed the volume-FTR relationship following pancreatic surgery.

Methods: All patients undergoing pancreatectomy between 2012 and 2015 were included. FTR is defined as the 90-day POM rate among patients with major complications. According to the spline model, the critical cutoff was 20 resections per year and hospitals were divided into low (<10 resections/an), intermediate (11–19 resections/yr), and high volume centers (≥20 resections/yr).

Results: Overall, 12,333 patients who underwent pancreatectomy were identified. The POM was 6.9% and decreased significantly with increased hospital volume. The rate of FTR was 14.5% and varied significantly with hospital volume (18.3% in low hospital volume vs 11.9% in high hospital volume, P < 0.001), age (P < 0.001) and ChCl (CCl0-2: 11.5%, ChCl3: 13%, CCl ≥4:18.6%; P < 0.001). FTR for renal failure was the highest of all complications (40.2%), followed by postoperative shock (36.4%) and cardiac complications (35.1%). The FTR was significantly higher in low and intermediate compared with high volume hospitals for shock, digestive, and thromboembolic complications and reoperation. In multivariable analysis, intermediate (OR = 1.265, CI95%[1.103–1.701], P = 0.045) and low volume centers (OR = 1.536, CI95%[1.165–2.025], P = 0.002) were independently associated with increased FTR rates.

Conclusion: FTR after pancreatectomy is high and directly correlated to hospital volume, highlighting variability in the management of postoperative complications. Measurement of the FTR rate should become a standard for quality improvement programs.

*Department of Digestive Surgery and Transplantation, Lille University Hospital, Lille, France

University of Lille, Lille, France

Medical Information Department, Lille University Hospital, Lille, France

§Department of HPB and Pancreatic Surgery, AP-HP Beaujon Hospital, Clichy, France

Department of Surgery, Institut Paoli Calmettes, Marseille, France.

Reprints: Mehdi El Amrani, MD, Service de Chirurgie Digestive et Transplantation, Hôpital CLAUDE HURIEZ, Rue Michel Polonovski, 59037 Lille Cedex, France. E-mail:

The authors report no conflicts of interest.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (

Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.