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To What Extent Does Posthospital Discharge Chemoprophylaxis Prevent Venous Thromboembolism After Bariatric Surgery?

Results From a Nationwide Cohort of More Than 110,000 Patients

Thereaux, Jérémie MD, PhD*,†,‡; Lesuffleur, Thomas MD*; Czernichow, Sébastien MD, PhD§; Basdevant, Arnaud MD, PhD; Msika, Simon MD, PhD||; Nocca, David MD, PhD**; Millat, Bertrand MD, PhD*; Fagot-Campagna, Anne MD, PhD*

doi: 10.1097/SLA.0000000000002285

Objective: The aim of the present study was to assess the incidence, risk factors, and the impact of posthospital discharge (PHD) chemoprophylaxis on venous thromboembolism (VTE) in patients undergoing bariatric surgery (BS).

Background: VTE is a major concern after BS, especially during the PHD period. No large-scale study has previously focused on the clinical value of PHD chemoprophylaxis.

Methods: In this nationwide observational population-based cohort study, all data from patients undergoing BS were extracted from the French National Health Insurance database (SNIIRAM) from 1st January 2012 to 31st September 2014. Logistic regression models were used to compute odds ratios for potential risk factors for VTE occurring within 90 postoperative days (PODs). The association between use of PHD chemoprophylaxis (heparin) and VTE was also assessed.

Results: The majority (56%) of the 110,824 patients had sleeve gastrectomy. VTE rates during the first 30 and 90 PODs were 0.34% and 0.51%, respectively. On multivariate analyses, the major risk factors for VTE during the first 90 PODs were history of VTE [odds ratio = 6.33 95% confidence interval (4.44–9.00)], postoperative complications [9.23 (7.30–11.70)], heart failure [2.45 (1.48–4.06)], and open surgery [2.38 (1.59–3.45)]. PHD chemoprophylaxis was delivered to 75% of patients. No use of PHD chemoprophylaxis [1.27 (1.01–1.61)] was an independent predictive factor of VTE during the first 90 PODs [in the gastric bypass group: 1.51 (1.01–2.29)).

Conclusions: In the modern era of BS, this nationwide study shows a non-negligible rate of VTE especially after sleeve gastrectomy, depending on the individual risk level. Use of PHD chemoprophylaxis may decrease the risk of PHD VTE.

*Department of Statistics, Caisse Nationale d’Assurance Maladie des Travailleurs Salariés (CNAMTS), Paris, France

Department of General, Digestive and Metabolic Surgery, La Cavale Blanche University Hospital, Boulevard Tanguy Prigent, Brest, France

University of Bretagne Occidentale (UBO), EA 3878 Brest, France

§Department of Nutrition, Hopital Européen Georges-Pompidou, Centre Spécialisé Obésité Ile de France Sud, Paris Descartes University, Assistance Publique-Hôpitaux de Paris, Paris, France

Heart and Nutrition Department, Institute of Cardiometabolism and Nutrition (ICAN), Assistance-Publique Hôpitaux de Paris, Pitié-Salpêtrière Hospital, France Sorbonne Universities, University Pierre et Marie Curie-Paris 6, Boulevard de l’Hôpital, Paris, France

||Department of General, Digestive and Metabolic Surgery, Louis Mourier Hospital, Assistance Publique-Hôpitaux de Paris, Diderot Paris 7 University, Colombes, Paris, France

**Department of Surgery, CHU Montpellier, Faculty of Medicine of Montpellier, Montpellier, France.

Reprints: Anne Fagot-Campagna, MD, PhD, Department of Statistics, Caisse Nationale d’Assurance Maladie des Travailleurs Salariés (CNAMTS), 50 Avenue du Professeur André Lemierre, 75896 Paris Cedex 20, France. E-mail:

Disclosures: The authors report no conflicts of interest.

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