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Predictive Factors for the Metachronous Development of High-risk Lesions in the Remnant Pancreas After Partial Pancreatectomy for Intraductal Papillary Mucinous Neoplasm

Miyasaka, Yoshihiro MD, PhD; Ohtsuka, Takao MD, PhD; Tamura, Koji MD; Mori, Yasuhisa MD, PhD; Shindo, Koji MD, PhD; Yamada, Daisuke MD, PhD; Takahata, Shunichi MD, PhD; Ishigami, Kousei MD, PhD; Ito, Tetsuhide MD, PhD; Tokunaga, Shoji PhD; Oda, Yoshinao MD, PhD; Mizumoto, Kazuhiro MD, PhD; Nakamura, Masafumi MD, PhD; Tanaka, Masao MD, PhD, FACS

doi: 10.1097/SLA.0000000000001368
ORIGINAL ARTICLES
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Objective: To identify factors predicting the development of high-risk lesions in the remnant pancreas after surgery for intraductal papillary mucinous neoplasm (IPMN).

Background: IPMN has unique features, including multifocality, adenoma-carcinoma sequence, and the development of distinct pancreatic ductal adenocarcinoma (PDAC) in the same pancreas. Careful attention should, therefore, be paid to the metachronous occurrence of high-risk lesions, including high-grade dysplasia or invasive carcinoma (HGD/INV) of IPMN and concomitant PDAC in the remnant pancreas after partial pancreatectomy for IPMN.

Methods: Clinicopathologic and surveillance data for 195 patients who underwent partial pancreatectomy for IPMN were reviewed retrospectively.

Results: Thirteen patients exhibited metachronous development of high-risk lesions including 6 HGD/INV and 7 concomitant PDACs in the remnant pancreas. The 5- and 10-year cumulative incidences of metachronous high-risk lesions in the remnant pancreas were 7.8% and 11.8%, respectively. Twelve of 13 patients had high-risk lesions at the time of initial surgery, and 10 of the 13 IPMNs were located in the distal pancreas. The IPMN subtypes initially resected were gastric in 6 patients, intestinal in 5, and pancreatobililary in the remaining 2. Univariate and multiple regression analyses identified pathologic results of HGD/INV and IPMN located in the distal pancreas as independent predictive factors for metachronous HGD/INV of IPMN, and the pancreatobiliary subtype of IPMN and presence of concomitant PDAC for metachronous PDAC.

Conclusions: Patients undergoing partial pancreatectomy for IPMN are at high risk of developing lesions requiring surgery in the remnant pancreas, and close, long-term surveillance should be considered in these patients.

*Departments of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

§Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

||The Medical Information Center and Cancer Center, Kyushu University Hospital, Fukuoka, Japan.

Reprints: Masao Tanaka, MD, PhD, FACS, Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3–1–1 Maidashi, Higashi-ku, Fukuoka 812–8582, Japan. E-mail: masaotan@surg1.med.kyushu-u.ac.jp.

Disclosure: Supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI (No. 25462117, 25293285). The authors declare no conflicts of interest.

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