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A Randomized Controlled Trial of Vagus Nerve-preserving Distal Gastrectomy Versus Conventional Distal Gastrectomy for Postoperative Quality of Life in Early Stage Gastric Cancer Patients

Kim, Su Mi MD; Cho, Juhee PhD; Kang, Danbee; Oh, Seung Jong MD; Kim, Ae Ran MSN; Sohn, Tae Sung MD, PhD; Noh, Jae Hyoung; Kim, Sung

doi: 10.1097/SLA.0000000000001565
RANDOMIZED CONTROLLED TRIALS
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Objective: To compare the postoperative quality of life of vagus nerve preserving distal gastrectomy (VPG) vs conventional distal gastrectomy (CG) in patients with early-stage gastric cancer.

Design: Randomized controlled clinical trial.

Setting: Large tertiary comprehensive cancer center in Korea.

Participants: One hundred sixty-three patients with early gastric cancer 18 years of age or older expected to undergo curative gastric resection.

Intervention: Patients were randomized 1:1 to VPG (n = 85) or CG (n = 78).

Main outcome measures: European Organization for Research and Treatment of Cancer (EORTC) gastric module (STO22).

Results: Patients assigned to VPG showed less diarrhea 3 and 12 months after surgery (P = 0.040 and 0.048, respectively) and less appetite loss at 12 months (P = 0.011) compared with those assigned to CG. In both groups, fatigue, anxiety, eating restriction, and body image deteriorated at 3 months after surgery and did not regain baseline levels 12 months after surgery. There were no significant differences between the 2 groups in cancer recurrence and death over 5 years of follow-up.

Conclusions: Early gastric cancer patients undergoing VPG reported significantly less diarrhea and appetite loss at 12 months postsurgery compared with those undergoing CG, with no differences in long-term clinical outcomes. VPG may improve the quality of life after gastrectomy in early gastric cancer patients compared with CG.

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*Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Cancer Education Center, Samsung Medical Center, Sungkyunkwan University School of Medicine and Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea

Departments of Epidemiology and Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD

§Department of Surgery, National Police Hospital, Seoul, Korea

Department of Nursing, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Reprints: Sung Kim, MD, PhD, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro Gangnam-gu, Seoul 06351, Korea. E-mail: skim.kim@samsung.com.

Su Mi Kim and Juhee Cho equally contribute to this paper.

The authors have no conflicts of interest, financial or otherwise.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.annalsofsurgery.com).

Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.