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Incidence and Risks of Liver Resection: An All-Inclusive French Nationwide Study

Farges, Olivier MD, PhD*; Goutte, Nathalie BSc; Bendersky, Noelle MD; Falissard, Bruno MD, PhD§

doi: 10.1097/SLA.0b013e31827241d5
Original Articles From the ESA Proceedings

Objective: To evaluate at a national level the incidence of liver resection, postoperative mortality, and variables that predict this outcome.

Background: Data on indications of and results of liver resection are mainly derived from high-volume centers. Nationwide data are lacking.

Methods: French health care databases were screened to identify all patients who had undergone elective hepatectomy between 2007 and 2010. The patients' age, address, associated conditions, indication and extent of hepatic (or extrahepatic) surgery and the hospital type, location, and hepatectomy caseload were retrieved. Logistic regression was used to measure the influence of these parameters on in-hospital and 90-day mortality rates. The model, created using patients operated on in 2007 and 2009, was tested in those operated on in 2008 and 2010.

Results: Overall, 28,708 hepatectomies were performed. The annual incidence (13.2 per 105 adult inhabitants) varied between regions, but the extremal quotient was limited to 2.2 because 15% of the operations took place outside the patients' home region. Hospitals performed a median of 4 resections per year but 53% of all resections were performed in institutions with a volume of more than 50 per year. Treatment for primary tumors and major resections correlated with hepatectomy caseload. In-hospital and 90-day mortality were 3.4% and 5.8%, respectively. The area under the receiver operating characteristic curve of the prognostic model was 0.78/0.77 in the training and validation sample.

Conclusions: There were significant disparities in practice. In-hospital mortality underestimated true, postoperative mortality by more than 50%. The model created may be useful for more efficient regionalization of care and patient counseling.

Supplemental Digital Content is Available in the Text.This nationwide French, all-inclusive analysis of 28,708 patients found that the incidence of liver resection is higher than previously reported. It describes the indications for as well as extent of surgery and provides an accurate, validated, prognostic model of the risk of postoperative mortality.

*Department of Hepatobiliopancreatic Surgery and Liver Transplantation

Department of Hepatology

Department of Medical Informatics, Hôpital Beaujon, AP-HP, Université Paris 7, Clichy, France

§INSERM U669, Université Paris 11, France.

Reprints: Olivier Farges, MD, PhD, Department of HPB Surgery, Hôpital Beaujon, 100 bld du General Leclerc, F-92118 Clichy, France. E-mail:

The ACHBT-French Hepatectomy study group (in alphabetical order) is comprised of the following members: René Adam, Mustapha Adham, Philippe Bachellier, Jacques Belghiti, Emmanuel Boleslawski, Denis Castaing, Cécile Chevance, Jean-Robert Delpero, Christian Ducerf, Dominique Elias, Jean Hardwigsen, Christophe Laurent, Yves-Patrice Le Treut, Jean Yves Mabrut, Jean Mantz, François Paye, François René Pruvot, Jean Marc Regimbeau, Olivier Scatton, Olivier Soubrane, Eric Vibert.

Disclosure: The authors declare no conflicts of interest. This study was funded by a Programme Hospitalier de Recherche Clinique grant (PHRC National 2011, AOM 11060) from the French Ministry of Health awarded to OF and by the Association de Chirurgie Hepato-Biliaire et de Transplantation Hépatique.

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© 2012 Lippincott Williams & Wilkins, Inc.