The objective of the HASTA trial was to compare hand suture
versus stapling loop ileostomy closure
in a randomized controlled trial.
Bowel obstruction is one of the main and the clinically and economically most relevant complication following closure of loop ileostomy after low anterior resection. The best surgical technique for closure of loop ileostomy has not been defined yet.
HASTA trial is a multicenter pragmatic randomized controlled surgical trial with 2 parallel groups to compare hand suture
versus stapling for closure of loop ileostomy. The primary endpoint was the rate of bowel obstruction within 30 days after ileostomy closure
A total of 337 randomized patients undergoing closure of loop ileostomy after low anterior resection because of rectal cancer in 27 centers were included. The overall rate of postoperative ileus
after ileostomy closure
was 13.4%. Seventeen of 165 (10.3%) patients in the stapler group and 27 of 163 (16.6%) in the hand suture
group developed bowel obstruction within 30 days postoperatively [odds ratio (OR) = 1.72; 95% confidence interval (CI): 0.89–3.31 = 0.10]. Duration of surgical intervention was significantly shorter in the stapler group (15 minutes; P
< 0.001). Multivariable analysis of potential risk factors did not reveal any significant correlation with development of postoperative ileus
. Rate of anastomotic leakage (stapler: 3.0%, hand suture
: 1.8%, P
= 0.48) did not differ significantly as well as all other secondary endpoints.
Hand-sewn anastomosis versus stapler ileo-ileostomy for ileostomy closure
are equally effective in terms of postoperative bowel obstruction, with stapler anastomosis leading to a shorter operation time. Postoperative ileus
after ileostomy reversal remains a relevant complication.