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Value of 18-Fluorodeoxyglucose Positron Emission Tomography in the Management of Patients With Cystic Tumors of the Pancreas

Sperti, Cosimo MD*; Pasquali, Claudio MD*; Chierichetti, Franca MD; Liessi, Guido MD; Ferlin, Giorgio MD; Pedrazzoli, Sergio MD, FACS*

Original Articles
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Objective To assess the reliability of 18-fluorodeoxyglucose positron emission tomography (18-FDG PET) in distinguishing benign from malignant cystic lesions of the pancreas.

Summary Background Data The preoperative differential diagnosis of cystic lesions of the pancreas remains difficult: the most important point is to identify malignant or premalignant cysts that require resection. 18-FDG PET is a new imaging procedure based on the increased glucose metabolism by tumor cells and has been proposed for the diagnosis and staging of pancreatic cancer.

Methods During a 4-year period, 56 patients with a suspected cystic tumor of the pancreas underwent 18-FDG PET in addition to computed tomography scanning, serum CA 19-9 assay, and in some instances magnetic resonance imaging or endoscopic retrograde cholangiopancreatography. The 18-FDG PET was analyzed visually and semiquantitatively using the standard uptake value. The accuracy of 18-FDG PET and computed tomography was determined for preoperative diagnosis of a malignant cyst.

Results Seventeen patients had malignant tumors. Sixteen patients (94%) showed 18-FDG uptake with a standard uptake value of 2.6 to 12.0. Twelve patients (70%) were correctly identified as having malignancy by computed tomography, CA 19-9 assay, or both. Thirty-nine patients had benign tumors: only one mucinous cystadenoma showed increased 18-FDG uptake (standard uptake value 2.6). Five patients with benign cysts showed computed tomography findings of malignancy. Sensitivity, specificity, and positive and negative predictive values for 18-FDG PET and computed tomography scanning in detecting malignant tumors were 94%, 97%, 94%, and 97% and 65%, 87%, 69%, and 85%, respectively.

Conclusions 18-FDG PET is more accurate than computed tomography in identifying malignant pancreatic cystic lesions and should be used, in combination with computed tomography and tumor markers assay, in the preoperative evaluation of patients with pancreatic cystic lesions. A positive result on 18-FDG PET strongly suggests malignancy and, therefore, a need for resection; a negative result shows a benign tumor that may be treated with limited resection or, in selected high-risk patients, with biopsy, follow-up, or both.

From the *Departments of Medical and Surgical Sciences, University of Padua, Padua; and the Departments of †Nuclear Medicine and ‡Radiology, Castelfranco Hospital, Castelfranco Veneto, Treviso, Italy

Supported in part by grants from the Italian Ministry for the University, Scientific and Technological Research (MURST), projects #9906218982 and #9906195987.

Correspondence: Claudio Pasquali, MD, Semeiotica Chirurgica, Ospedale Busonera, via Gattamelata 64, 35128 Padova, Italy.

E-mail: cpasqual@ux1.unipd.it

Accepted for publication February 1, 2001.

© 2001 Lippincott Williams & Wilkins, Inc.