LOZMAN JEFFREY M.D.; DUTTON, ROBERT E. M.D.; NEWELL, JONATHAN Ph.D.; POWERS, SAMUEL R. Jr., M.D.Annals of Surgery: November 1977 Article: PDF Only Buy Abstract Abstract Ventilatory function of the lungs has been studied in 13 posttrauma patients using a two compartment analysis. The analysis is based upon a model of the lung which describes a nitrogen washout curve in terms of fast and slowly ventilated compartments. Data output from a digital computer provides values that compare the fractions of the alveolar ventilation and volume of the two compartments. All patients on initial investigation had large identifiable slow spaces. Subsequent evaluation at a time of clinical improvement showed that the ventilation of the slow space had increased significantly (P < .003), whereas no change was evident in the volume fraction. The ventilation to volume ration of the slow space, measured on these two separate occasions increased in twelve of the patients studied. An increase in this ratio correlated with improvement in the patient's clinical condition. © Lippincott-Raven Publishers.